Results 251 to 260 of about 2,800,842 (301)
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
Advanced Science, EarlyView.This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen +16 more
wiley +1 more source
NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis
Advanced Science, EarlyView.In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu +11 more
wiley +1 more source
Shared and Unique Neural Codes for Biological Motion Perception in Humans and Macaque Monkeys
Advanced Science, EarlyView.Cross‐species fMRI studies reveal distinct neural mechanisms for biological motion (BM) processing. In humans, the posterior superior temporal sulcus (hpSTS) selectively responds to conspecific BM, while monkeys process BM from both species in the middle temporal area (MT).
Yuhui Cheng +7 more
wiley +1 more source
Electrostatically Reinforced Double Network Granular Hydrogels
Advanced Science, EarlyView.Electrostatically reinforced double network granular hydrogels (DNGHs) with cartilage‐like fracture energy are introduced. An empirical model predicts the composition‐dependent fracture energy based on dissipation zone size, contact area, and inter‐particle adhesion energy. Thanks to their granular structure and the inter‐particle attraction, the DNGHs
Tianyu Yuan +3 more
wiley +1 more source
Advanced Science, EarlyView.A new analytical pipeline, FREQuency‐resolved Network Estimation via Source Separation (FREQ‐NESS), reveals how the brain at rest is organized in frequency‐specific networks and dynamically rearranges during auditory stimulation. By analyzing source‐reconstructed magnetoencephalography (MEG) data, FREQ‐NESS uncovers the networks' prominence, spatial ...
Mattia Rosso +6 more
wiley +1 more source
Machine Learning‐Enabled Drug‐Induced Toxicity Prediction
Advanced Science, EarlyView.Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai +5 more
wiley +1 more source
Advanced Science, EarlyView.An automated tool incorporating a large language model (LLM) streamlines the extraction and classification of protein expression and purification methods from 64 909 PDB‐associated articles. By identifying trends in buffer components, fusion tags, expression conditions, and crosslinker/detergent preferences, the tool provides valuable insights into the
Zhuojian Chen, J. Sivaraman
wiley +1 more source
Advanced Science, EarlyView.A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan +12 more
wiley +1 more source