Results 231 to 240 of about 3,265,059 (298)

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

An analysis of global legislation and regulation related to drowning prevention. [PDF]

PLOS Glob Public Health
Essex R, Jagnoor J.
europepmc   +1 more source

Thickness-Dependent Creep in Lithium Layers of All-Solid-State Batteries under Stack Pressures. [PDF]

Adv Sci (Weinh)
Duan C, Feng Y, Lin T, Ye R, Li M, Wen J, Chen C, Wei Y.   +7 more
europepmc   +1 more source

Investigating DNA words and their distributions across the tree of life. [PDF]

Comput Struct Biotechnol J
Koilakos C, Provatas K, Patsakis M, Karatzikos A, Tzanakakis A, Georgakopoulos-Soares I.   +5 more
europepmc   +1 more source

Study on the evolution law of failure depth of large mining height and ultra-wide working surface. [PDF]

Sci Rep
Wang W, Li Z, Du F, Cao Z, Shi J, Zhai M, Liu M.   +6 more
europepmc   +1 more source

Experimental investigation of mechanical properties in cryogenically damaged shale. [PDF]

Sci Rep
Zheng X, Zhang G, Wang D, Yang F, Lu M, Song L, Zhou D.   +6 more
europepmc   +1 more source

Activity constraints and the emergence of non-scale-free networks: Evidence from hip-hop and academia. [PDF]

PLoS One
Lee J, Li Y.
europepmc   +1 more source