Results 211 to 220 of about 1,772,940 (347)

Natural heritage and modern armed conflicts: ethical approach and international humanitarian law

, 2018
Svyatoslav Sergeevich Gorbunov
openalex   +2 more sources

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Review of "The First Grace: Rediscovering the Natural Law in a Post-Christian World" by Russell Hittinger

, 2012
Mary M. Keys
openalex   +1 more source

FROM PHENOMENA AND LAWS OF NATURE TO INITIAL DATA SYMMETRY PRINCIPLES (EXPERIENCE OF RELATIONSHIP OF NATURAL SCIENCE AND THEOLOGY)

, 2015
V. N. Pervushin
openalex   +2 more sources

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Experimental study and evaluation analysis on the plugging mechanism of sand control screen in argillaceous Fine-Silt gas hydrate reservoirs. [PDF]

Sci Rep
Wang EC, Liao H, Zhang HE.
europepmc   +1 more source

Definition of natural resources in international law

Sergіy Bilotsky
openalex   +2 more sources

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

State Gun Laws and Firearm Suicide Rates.

JAMA Netw Open
Goh M, Fleegler EW, Siegel M.
europepmc   +1 more source

The policy exposome of dementia: Gaps, opportunities, and research agenda. [PDF]

Alzheimers Dement
Kieny C, Marks G, Bourgeois M, Alladi S, Atshan S, Brayne C, Dow W, Glymour M, Knapp D, Livingston G, Mahmud M, Monnet N, Papanicolas I, Platt E, Rehkopf D, Sadana R, Wallace L, Walsh S, Wenner M, Avendano M.   +19 more
europepmc   +1 more source