Results 51 to 60 of about 75,668 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Balancing the Energy Efficiency Benefits of Glazed Surfaces: A Case Study

Buildings
Daylighting design is not only dimensioning glazed surfaces to provide sufficient natural light to an occupied space but also a method of analyzing how this can be achieved without unwanted effects, such as gains and losses of heat, glare, and variations
Dorina-Nicolina Isopescu, Catalin-Daniel Galatanu, Alexandra Ungureanu, Sebastian-George Maxineasa, Ioana-Roxana Vizitiu-Baciu, Andreea Nistorac, Ligia Mihaela Moga   +6 more
doaj   +1 more source

Experiment on increasing solar radiation for building by using “Smart Mirror”

Journal of Asian Architecture and Building Engineering, 2019
The mode of solar energy utilization includes PV, solar heating，hot water and so on, but it is difficult to improve the utilization rate nowadays. Using computer technology, a Smart Mirror was developed and installed on the roof of a building in Beijing,
Zhengwang Wu, Yang Yan, Yue Di
doaj   +1 more source

The Analysis of Natural Lighting-based Visual Comfort for Classrooms Building by Using Velux Daylight Visualizer [PDF]

E3S Web of Conferences
This study aims to determine the level of natural lighting at a school building carried out with the use of the Velux Daylight Visualizer (VDV) software. VDV is a software for analysing natural lighting on building model.
Hajji Apif M., Satria Shidiq Y., Alfianto Imam   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Impact of Sociocultural Aspects on Energy Consumption in Residential Buildings in Riyadh, Saudi Arabia

Architecture
This study explores the intersection of sociocultural factors, particularly privacy, with energy consumption patterns in residential buildings in Riyadh, Saudi Arabia.
Reem Jandali, Ahmad Taki, Sahar Abdelwahab   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Architectural Retrofitting to Enhance Daylighting and Improve Energy Performance: A Food-Retail Case Study

Energies
Artificial lighting accounts for roughly 30% of total electricity use in supermarkets and significantly affects product perception, customer experience, and purchasing behavior.
Simone Forastiere, Carla Balocco, Cristina Piselli, Fabio Sciurpi, Maider Llaguno-Munitxa   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Hybrid lighting approach to improve interior workspace environments: a case study in the UAE [PDF]

Frontiers in Engineering and Built Environment
Purpose – Interior workspace environments use exclusively artificial light, resulting in a loss of biological connection and natural light quality, as well as greater energy consumption.
Mohammed Al Kailani, Aysha Al Dhaheri, Wael Sheta   +2 more
doaj   +1 more source