Results 81 to 90 of about 532,772 (349)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Intervención en el edificio Clave: Valparaíso, Chile

ARQ, 2010
Como resultado de un proyecto de título que estudia el plan de Valparaíso -con sus diferentes modos de ocupación de las manzanas-, se presenta la posibilidad de intervenir un edificio de viviendas en la base del cerro Cordillera, a partir de la ...
Daniel Ruddoff
doaj  

Claroscuro Secuencial. La luz como proyecto

Area
Claroscuro Secuencial propone la luz como una herramienta proyectual clave en la Arquitectura, permitiendo desarrollar sistemas que exploran el vínculo recíproco y sistemático entre la luz y la forma arquitectónica.
Nicolás Pablo Neira
doaj   +1 more source

Problems of natural lighting for deepened buildings and underground premises under screen effect of high-rise construction

E3S Web of Conferences, 2018
The main rationale and objective of the submitted research work is to create a quality lighting environment in the premises of deepened buildings and below-ground structures under screen effect of high-rise construction (high-rise buildings). It is noted,
Larionova Kira, Stetsky Sergey
doaj   +1 more source

Improving the reliability of the automatic lightings functioning with non-quality electricity [PDF]

, 2018
Питання впровадження енергозберігаючих технологій в освітлені, особливо в умовах безперервного зростання вартості електроенергії, актуальне і може суттєво знизити споживання електроенергії.
Косарєв, Євген Миколайович, Малиш, Сергій Миколайович, Пилипчук, Володимир Петрович, Сиченко, Віктор Григорович, Ширяєв, Валерій Семенович   +4 more
core   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A simulation study on the interactive effects of radiation and plant density on growth of cut chrysanthemum [PDF]

, 2002
In the present study, we used a photosynthesis-driven crop growth model to determine acceptable plant densities for cut chrysanthemum throughout the year at different intensities of supplementary light.
Challa, H., Heuvelink, E., Lee, J.H.
core   +3 more sources

Natural supersymmetry without light Higgsinos

Physical Review D, 2015
22 pages, 2 figures; v2: references ...
Cohen, Timothy, Kearney, John, Luty, Markus   +2 more
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source