Results 31 to 40 of about 4,658,191 (250)

Quality of Life Among Natural Menopausal Women and Early Surgical Menopausal Women: A Study from Greece

Nursing Reports
Background/Objectives: The general health and well-being of middle-aged women have become a major public health issue worldwide. More than 80% of women experience physical or psychological symptoms during the transition to menopause.
Fotini Kavga, Anastasia Bothou, Christina Nanou, Giannoula Kyrkou, Victoria Vivilaki, Anna Deltsidou   +5 more
doaj   +1 more source

Age at Natural Menopause and Associated Influencing Factors: A Cross-Sectional Analysis From the Shahrekord Cohort Study [PDF]

Journal of Multidisciplinary Care
Background and aims: Menopause is a natural phase in a woman’s life that is influenced by various factors. This study aimed to identify the age at natural menopause and its associated factors within a large-scale, population-based cohort in Iran. Methods:
Sheida Shabanian, Masoumeh Moezzi, Ziba Raisi Dehkordi, Elham Amini, Ali Ahmadi   +4 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

3′‐UTR Hypermethylation and ABA Signaling Coordinate Transcriptional Activation of SWEET14 for High Sugar Accumulation in Citrus

Advanced Science, EarlyView.
Hypermethylation of CliSWEET14 3′‐UTR relieves ClibHLH105‐mediated transcriptional repression, together with ABA signaling‐mediated activation of the CliABF3‐CliNAC56 cascade, boosts CliSWEET14 expression and sucrose accumulation in citrus. ABSTRACT Sugar accumulation is pivotal for fruit quality, yet the molecular regulation of this process remains ...
Yike Zeng, Yue Wang, Yilei Wang, Haowei Chen, Qiyu Chen, Wei Xiao, Aoqing Zhang, Xin Jiang, Xiangming Shang, Zhicheng Yang, Xi Zeng, Wenqiang Hu, Chunlong Li, Ji‐Hong Liu   +13 more
wiley   +1 more source

Perception of menopause : black and white working-class women's experiences [PDF]

, 1997
Bibliography: leaves 138-146.This thesis aimed to address the ways in which class, race, culture, gender and power shape experiences of menopause by exploring the experiences of South African black and white working-class women. The main implications for
Orner, Phyllis
core   +1 more source

Associations of age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy with glycaemia and risk of dementia: a study based on the population-based UK Biobank cohort

BMJ Public Health
Introduction Menopausal factors, including age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy (HRT), have been associated with dementia risk, which might be due to increased glucose levels after menopause.
Patrick May, Anouk Geraets, Katherine Ford, Emma Kidd, Anja Leist   +4 more
doaj   +1 more source

Age at natural menopause and associated factors in adult women: Findings from the China Kadoorie Biobank study in Zhejiang rural area.

PLoS ONE, 2018
ObjectivesTo investigate the factors associated with age at natural menopause in a large population of Chinese adult women.MethodsThis cross-sectional study was part of the baseline survey of China Kadoorie Biobank in Zhejiang Province. A total of 17,076
Meng Wang, Wei-Wei Gong, Ru-Ying Hu, Hao Wang, Yu Guo, Zheng Bian, Jun Lv, Zheng-Ming Chen, Li-Ming Li, Min Yu   +9 more
doaj   +1 more source

Age at Natural Menopause and Related Factors in Isfahan, Iran

, 2016
OBJECTIVE: This study was aimed to evaluate the age at natural menopause and related factors among women in a population based study in 2015 in Isfahan, Islamic Republic of Iran.
Akbari, M., Abdollahzadeh, M. R., Golshiri, P.   +2 more
core   +1 more source