Results 91 to 100 of about 16,024,442 (290)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Optimization of heat transfer in a solid torus: A parametric and numerical approach under natural convection

Case Studies in Thermal Engineering
In the present work, a horizontally oriented 2D toroidal loop subjected to natural convection and surface radiation is studied numerically. The wall temperature of the torus and the adjacent air is considered to be 450 K and 300 K respectively. Influence
Kumud Ranjan, Gloria Biswal, Sachindra Kumar Rout, Ahmed Kadhim Hussein, Aboulbaba Eladeb, Badr M. Alshammari, Lioua Kolsi   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Experimental Study of Natural Convection Cooling of Vertical Cylinders with Inclined Plate Fins

Energies, 2016
In this paper, natural convection from vertical cylinders with inclined plate fins is investigated experimentally for use in cooling electronic equipment.
Jong Bum Lee, Hyun Jung Kim, Dong-Kwon Kim   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

On the Theoretically Possible Number of Cases in Natural Language

Дискурс
Introduction. The case, which is a semantic and grammatical category, appears in natural  languages in the most unexpected way. A word or phrase that has a substantive unit at its  core receives an inflection (internal or external) in one case or another,
V. N. Malysheva, A. A. Shumkov
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Type Specimens Of Birds In The American Museum Of Natural History Part 11. Passeriformes: Parulidae, Drepanididae, Vireonidae, Icteridae, Fringillinae, Carduelinae, Estrildidae, And Viduinae

, 2013
LeCroy, Mary (2013): Type Specimens Of Birds In The American Museum Of Natural History Part 11. Passeriformes: Parulidae, Drepanididae, Vireonidae, Icteridae, Fringillinae, Carduelinae, Estrildidae, And Viduinae.
Mary LeCroy, LeCroy, Mary, American Museum of Natural History   +2 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Natural Numbers

Crítica (México D. F. En línea), 1991
El segundo cuerno epistemológico del dilema de Benacerraf también puede verse como una serie de ideas metafísicas. ¿Cómo se ajustan sistemáticamente la mente, la materia y los abstracta absolutos (como los números) para que, por ejemplo, las mentes tengan conocimiento de los números?
openaire   +3 more sources