Results 51 to 60 of about 16,024,442 (290)
Natural Capital of Illinois [PDF]
, 1996 Made available in DSpace on 2009-03-30T17:23:00Z (GMT). No. of bitstreams: 3 inhscaev01996i00004_tei.xml: 91049 bytes, checksum: 1809a6c38a5ae9d89932b1fe7d6cc30b (MD5) inhscaev01996i00004_opt.pdf: 822978 bytes, checksum: 1cb2f5f66a2a65a2e8e5de4da661aceb (
Herendeen, Robert A., Mukherjee, Jaideep
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Final report to the Oregon Watershed Enhancement Board.KEYWORDS: Oregon, Willamette Valley Ecoregion, Benton County (Oregon), Dams, North Pacific coast, Tillamook County (Oregon), Aquatic resources, Management, Lincoln County (Oregon), Polk County ...
Oregon State University. Institute for Natural Resources
core +3 more sources
Applied Sciences, 2021 This work investigates a hydrodynamic problem involving the Fe3O4-Water nanofluid. The novelty of this investigation lies in the fact that the nanofluid free convection is evaluated within a specific rectangular enclosure having a finned absorber plate ...
Rached Nciri +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Effects of variations in magnetic Reynolds number on magnetic field distribution in electrically conducting fluid under magnetohydrodynamic natural convection [PDF]
Journal of Heat and Mass Transfer Research, 2017 In this study the effect of magnetic Reynolds number variation on magnetic distribution of natural convection heat transfer in an enclosure is numerically investigated.
Mohsen Pirmohammadi
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source