Results 81 to 90 of about 224,122 (308)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Disabled sports and physiological specificity in persons with spinal cord injury

open access: yesJournal of Physical Fitness and Sports Medicine, 2014
Today, a large proportion of persons with spinal cord injury (SCI) can return to society thanks to advances in biomedical care. Various sports activities are recommended, especially for wheelchair-bound disabled persons with SCI, in order to maintain ...
Takeshi Nakamura   +11 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Konstitusionele voorskrifte rakende regspersone [PDF]

open access: yesPotchefstroom Electronic Law Journal, 1998
The interim Constitution of 1993 and the final Constitution of 1996 contain specific provisions applicable to juristic persons. Juristic persons are also entitled to the fundamental rights contained in the Bill of Rights to the extent that these rights ...
GJ Pienaar
doaj  

A SOCIAL PSYCHOLOGICAL STUDY OF MEASURES FOR HELPING PERSONS BEREAVED DUE TO NATURAL DISASTERS

open access: yes, 1992
The objective of this study was to seek measures that would help ordinary people alleviate the grief of those who have lost family members in a natural disaster.
Kawakami, Yoshiro   +4 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Natural Unity and Paradoxes of Legal Persons [PDF]

open access: yes, 2014
This essay proposes an ontological model in which a legal person such as a polity possesses natural unity from group properties that emerge in the self-organization of the human population. Also, analysis of customary legal persons and property indicates
Goetz, James
core   +1 more source

Măsurile contractuale și judiciare de ocrotire a persoanei fizice adulte: noțiuni introductive

open access: yesRevista Institutului Naţional de Justiţie, 2018
Defining aspects on the contractual and judicial protection measures of adult natural persons The legal capacity of natural persons has a different regulation into national law, so that natural persons cannot be claimed incapable.
Cazacu Doina
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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