Results 151 to 160 of about 5,234,766 (297)

Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos, Morgan C. Devore, Christina Lam, Courtney Park, Sanjay Bidichandani, David R. Lynch   +5 more
wiley   +1 more source

National Burden of Human Adenovirus Infections in China: A Community-Based Multiplier Modeling Study. [PDF]

J Med Virol
Feng Q, Dai A, Zhou X, Ma L, Zhang H, Qu R, Chen M, Chen J, Miao J, Qi J, Zhou W, Yao L, Cen M, Chen Z, Chen C, Zhou J, Yang S.   +16 more
europepmc   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Marburg virus persistence and clinical complications among recovered persons in Rwanda: a longitudinal study protocol. [PDF]

BMJ Open
Ngabonziza J, Seruyange E, Mohamed NS, Brangel P, Tuyishime A, Choi MJ, Dahlke C, Remera E, Kagame J, Kreuger MJ, Ahmed A, Mwungura JC, Rwagasore E, Gishoma D, Bergeron É, Umulisa MM, Montgomery J, Mukagatare I, Rojek A, Musafiri S, Dowling W, Muvunyi CM.   +21 more
europepmc   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Crisis affected people with intellectual disabilities: experiences of conflict, natural hazard related disaster, and public health emergencies. [PDF]

Front Psychiatry
Rohwerder B.
europepmc   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Epidemiology of and Risk Factors for Amebic Meningoencephalitis, Kerala, India, 2025. [PDF]

Emerg Infect Dis
Sivanandan H, Thangaraj JWV, Saritha A, Bhaskar A, Reghukumar A, Rahim AA, Vadakkayil B, Sujatha C, Amma KM, Thali MA, Amma PMT, Chandran P, Ravindran RM, Prakash R, Jacob SR, Vadekkandiyil S, Chenayil S, Bhaskarannair U, Saraswthy AG, Moorkoth AP, Kanchana BM, George B, Gopal D, Hassan H, Johnson J, Divakaran KR, Bhama MCS, Shaju M, Abraham M, Ramankutty NT, Sankar P, Sajeev P, Narayanankutty S, Sasikumari O, Muthukutty SC, Anish TS, Kadavath V, Raman A, Santhakumari BG, Ramakrishnan G, Panarkandy G, Puthanpurayil JM, Karippoth MN, Mohammed SA, Sugunan S, Gangadharan ST, Ushakumari A, Radhakrishnan C, Sreekumar E, Anaswara N, Indu PS, Pareri RK, Sunija S, Govindan SKK, Johnson J, Jaya AM, Sushan A, Vaman RS, Gopalakrishnan LG, Vijayalekshmi AP, Harikrishnan DK, Ramasamy S, Krishna NS, Kollengode VV, Joseph RK, Goyal V, Khobragade R, Murhekar MV, AME Study Group.   +68 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source