Results 121 to 130 of about 5,557,531 (299)
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
THE CONSEQUENCES OF ENGAGING THE CRIMINAL LIABILITY OF LEGAL PERSONS ON THE CRIMINAL LIABILITY OF NATURAL PERSONS [PDF]
Challenges of the Knowledge SocietyThis paper examines the relationship between the criminal liability of legal persons and the criminal liability of natural persons under Romanian criminal law.
Luca-Ioan PĂUN
doaj
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
THE TAX TREATMENT OF INCOME FOR INDIVIDUALS FROM INDEPENDENT ACTIVITIES PERFORMED INDIVIDUALLY [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria EconomieIndividuals who wish to regularly and continuously conduct independent activities to generate income from production, service provision, commerce, and liberal professions can choose one of the following organizational forms: • Individually: -
CIUMAG MARIN , CIUMAG ANCA
doaj
What is the Nature of the Creative Person?
Is creativity reserved for geniuses? If you’re a creative writer, can your originality transfer to other domains like business? What about creativity at different levels, like a gymnast who’s developed a new routine and won at the college level versus someone who’s won the Olympic gold?
Sarah Rezaei, Hansika Kapoor
openaire +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
Understanding Vulnerability to Natural Hazards of Displaced Persons in Cox’s Bazar
LandRefugee settlements are often positioned around natural borders, which often have a heightened danger of environmental hazards. Here, we aim to better understand why settlements are in environmentally vulnerable land and what social and physical factors ...
Jack Dano, Carly Ching, Muhammad H Zaman
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source