Results 81 to 90 of about 4,500,216 (288)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

[Natural foci of plague in India: epizootological characteristics].

Meditsinskaia parazitologiia i parazitarnye bolezni, 2009
In the first half of the 20th century, India was responsible for the incidence of plague in both Asia and the world. The early 21st century was marked by two new epidemic outbreaks of plague (in 2002 and 2004) in this country. The major characteristics of plagues in India, activation of which is a cause of new epidemic outbreaks and necessitates a ...
L P, Bazanova, A S, Maramovich, A Ia, Nikitin, S A, Kosilko, L P, Okunev, T I, Innokent'eva, G A, Voronova   +6 more
openaire   +1 more source

Modern Conception of the Control over the Abundance of Carriers and Vectors of Plague in the Territory of the Russian Federation

Проблемы особо опасных инфекций, 2012
Disinfestation and deratization remain the main ways of non-specific disease prophylaxis in natural plague foci. Modern strategies, tactics, methods and means of control over carriers and vectors of plague and associated infectious diseases are selected ...
A. N. Matrosov, A. A. Kuznetsov, T. V. Knyazeva, D. B. Verzhutsky, A. Ya. Nikitin, L. S. Nemchenko, M. P. Grigor'ev, B. I. Levchenko, O. A. Bobenko, A. Yu. Gazieva, V. B. Korotkov   +10 more
doaj   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

Soloviov Valentyn Ivanovych, an epizootologist, mammalogist, and ecologist [PDF]

Novitates Theriologicae, 2022
An essay about V. I. Soloviov, a zoologist, epizootologist, head of the zoological laboratory of Odessa Anti-Plague Institute. Valentyn Soloviov studied natural foci of particularly dangerous infections and the role of small mammals and their parasites ...
Svitlana Uzhevska, Dmytro Sokolovsky
doaj  

Persistence of Yersinia pestis in Soil Under Natural Conditions

Emerging Infectious Diseases, 2008
As part of a fatal human plague case investigation, we showed that the plague bacterium, Yersinia pestis, can survive for at least 24 days in contaminated soil under natural conditions.
Rebecca J. Eisen, Jeannine M. Petersen, Charles L. Higgins, David Wong, Craig E. Levy, Paul S. Mead, Martin E. Schriefer, Kevin S. Griffith, Kenneth L. Gage, Charles Ben Beard   +9 more
doaj   +1 more source

Inverse Design of Pre‐Strain via a Predictive Electromechanical Model for Enhanced Strain Sensing

Advanced Science, EarlyView.
An analytical electromechanical model rooted in microcrack evolution mechanics is globally calibrated from only eight pre‐strain datasets, enabling prediction of the complete sensing response at untested pre‐strain values within the calibrated design space (R2 > 0.99).
Jia‐Chen Shang, Rui Wang, Bo Lu, Ming‐Liang Song, Yu‐Yi Chen, Kuo Han, Xin‐Jie Feng, Bin Sun, Yao‐Guang Cao, Xiao‐Yu Yan, Shi‐Chun Yang   +10 more
wiley   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

PLAGUE: CASES OF HUMAN INFECTION IN THE USA NATURAL FOCI AND THE DIFFICULTY OF THEIR DETECTION

Journal of microbiology, epidemiology and immunobiology, 2016
In this work we analyze the epidemic situations with plague in the United States of America, which are linked to internal migration - infection in a natural focus and movement of a diseased person within the boundaries of this focus to another district, state or non-endemic territory, as well as with international migration of infected person during ...
openaire   +4 more sources