Results 121 to 130 of about 37,948 (196)

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 460-473, March 2025.
Abstract In oncology drug development, measuring drug concentrations at the tumor site and at the targeted receptor remains an ongoing challenge. Positron emission tomography (PET)‐imaging is a promising noninvasive method to quantify intratumor exposure of a radiolabeled drug (biodistribution data) and target saturation by treatment doses in vivo ...
Robin Michelet   +8 more
wiley   +1 more source

A Study of Natural Radioactivity Levels and Radon/Thoron Release Potential of Bedrock and Soil in Southeastern Ireland. [PDF]

open access: yesInt J Environ Res Public Health, 2021
Mousavi Aghdam M   +6 more
europepmc   +1 more source

The Next Frontier: Micro/Nanorobots Operating Inside the Living Body

open access: yesSmartBot, EarlyView.
Micro/nanorobots, with their tiny size and controllable motion capabilities, can perform complex and precise tasks in micro‐spaces, thus showing broad application prospects in the biomedical field. This review systematically summarizes the core advantages of micro/nanorobots in real‐time in vivo imaging, targeted drug delivery, and active barrier ...
Ningbo Yu   +5 more
wiley   +1 more source

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

open access: yesSmall, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom   +6 more
wiley   +1 more source

pH‐Responsive Nanoparticle‐Coated Calcium Phosphate Granules for Bone Cancer Therapy

open access: yesSmall, EarlyView.
We report β‐TCP granules functionalized with selenium‐doped mesoporous silica nanoparticles through pH‐responsive imine–alendronate interfacial linkers, enabling stable nanoparticle immobilization under physiological conditions and selective release in the acidic osteosarcoma microenvironment.
Lei He   +3 more
wiley   +1 more source

Radiometric Constraints on the Timing, Tempo, and Effects of Large Igneous Province Emplacement

open access: yesGeophysical Monograph Series, Page 27-82., 2021

Exploring the links between Large Igneous Provinces and dramatic environmental impact

An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Jennifer Kasbohm   +2 more
wiley  

+2 more sources

Radiological risk assessment of natural radioactivity in imported rice consumed in Ghana and its implications for food safety and public health. [PDF]

open access: yesSci Rep
Dickson-Agudey P   +7 more
europepmc   +1 more source

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