Results 211 to 220 of about 4,089,756 (336)

Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs

open access: yesCancer Science, EarlyView.
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi   +2 more
wiley   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

open access: yesCell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo   +6 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer   +4 more
wiley   +1 more source

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

open access: yesThe FEBS Journal, EarlyView.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa   +9 more
wiley   +1 more source

Natural radioactivity and radon exhalation rate of Sardinian dimension stones

open access: yesConstruction and Building Materials, 2020
V. Dentoni   +6 more
semanticscholar   +1 more source

RioM‐1: A New Calcite Reference Material for U‐Pb LA‐ICP‐MS Geochronology

open access: yesGeostandards and Geoanalytical Research, EarlyView.
Key Points RioM‐1 calcite was characterised for trace elements, U‐Pb geochronology, Sr and O isotopes using ID‐TIMS, LA‐ICP‐MS and SIMS. U‐Pb dates from ID‐TIMS and LA‐ICP‐MS across several independent laboratories returned identical results within uncertainty.
Marco Silva   +10 more
wiley   +1 more source

A Call to Industry: Unearthing Synergies in Subsurface Storage Technologies

open access: yesGreenhouse Gases: Science and Technology, EarlyView.
ABSTRACT Subsurface storage technologies (SSTs), including geological CO2 sequestration, underground hydrogen storage, compressed‑air energy storage and thermal energy storage, are emerging as a scalable route for industry to achieve the terawatt‑hour storage flexibility and permanent carbon removal that evolving energy systems demand.
Julien Mouli‐Castillo   +2 more
wiley   +1 more source

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