Results 51 to 60 of about 933,827 (300)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Journal of Threatened Taxa, 2020 Illegal hunting and trading of the Chinese Pangolin Manis pentadactyla has pushed this Critically Endangered species close to extinction. While local reports have suggested its continued presence in mainland China, this has not been confirmed by a ...
Hongying Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Bryophytes of Mona Island Natural Reserve, Puerto Rico [PDF]
, 1998 This checklist provides in addition to a list of mosses and hepatics, a key to the species. We report 17 moss species of which 9 are new to Mona Island and 3 are new records for Puerto Rico (Fissidens minutus, Plaubelia sprengelii and Brymela ...
Reyes-Colón, Carmen M. +1 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Global distribution of two fungal pathogens threatening endangered sea turtles [PDF]
, 2014 This work was supported by grants of Ministerio de Ciencia e Innovación, Spain (CGL2009-10032, CGL2012-32934). J.M.S.R was supported by PhD fellowship of the CSIC (JAEPre 0901804).
A Gargas +62 more
core +5 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Perspectives on conservation grazing: The need for monitoring and communication
Ecological Solutions and EvidenceConservation grazing is widely used to manage open ecosystems, but inconsistent definitions and inadequate reporting of grazing patterns hinder effective communication among researchers, practitioners and policymakers, limiting the understanding and ...
Jonathan Millett +9 more
doaj +1 more source
Fauna of the species of the genus Rhaphium Meigen, 1803 (Diptera: Dolichopodidae) Krasnoyarsk region [PDF]
Кавказский энтомологический бюллетень, 2006 21 species of the genus Rhaphium are recorded for Krasnoyarsk region, 4 of them are listed for Siberia for the first time.
O.P. Negrobov, S.V. Pogonin
doaj +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source