Results 111 to 120 of about 2,099,317 (301)

Analysis of the Status and Tendency of R&D Input in the Field of Rare Diseases Funded by the National Natural Science Foundation of China. [PDF]

Front Public Health, 2021
Chang H, Chu W, Li X, Ma J, Li D, Yuan N.   +5 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Willems, Harco / Dahms, Jan-Michael (Hg.): The Nile: Natural and Cultural Landscape in Egypt. Bielefeld: transcript Verlag 2017. 370 S. m. Abb. 8° = Mainz Historical Cultural Sciences 36. Brosch. 29,99. ISBN 978-3-8376-3615-4. [PDF]

, 2020
Marcus Müller
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Natural Sciences [PDF]

The Elementary School Teacher, 1903
Professor Jackman, Associate Professor Baber   +1 more
openaire   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Use of Multimedia Interactive based on PjBL (Project Based-Learning): Study Effectiveness of Student Creativity in Subject Natural Sciences

, 2021
Ahmad Habib, I Made Astra, Erry Utomo
openalex   +2 more sources

Knowledge Priorities on Climate Change and Water in the Upper Indus Basin: A Horizon Scanning Exercise to Identify the Top 100 Research Questions in Social and Natural Sciences [PDF]

, 2022
Andrew Orr, Bashir Ahmad, Undala Alam, ArivudaiNambi Appadurai, Zareen Pervez Bharucha, Hester Biemans, Tobias Bolch, Narayan Prasad Chaulagain, Sanita Dhaubanjar, A. P. Dimri, Harry Dixon, Hayley J. Fowler, Giovanna Gioli, Sarah J. Halvorson, Abid Hussain, Ghulam Jeelani, Simi Kamal, Imran S. Khalid, Shiyin Liu, Arthur Lutz, Meeta Keswani Mehra, Evan Miles, Andrea Momblanch, Veruska Muccione, Aditi Mukherji, Daanish Mustafa, Omaid Najmuddin, Mohammad Nasim Nasimi, Marcus Nüsser, Vishnu Prasad Pandey, Sitara Parveen, Francesca Pellicciotti, Carmel Pollino, Emily Potter, Mohammad R. Qazizada, Saon Ray, Shakil Ahmad Romshoo, Syamal K. Sarkar, Amiera Sawas, Sumit Sen, Attaullah Shah, Muhammad Azeem Ali Shah, J. M. Shea, Ali T. Sheikh, A. B. Shrestha, Shresth Tayal, Snehlata Tigala, Zeeshan Tahir Virk, P. Wester, James L. Wescoat   +49 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source