Results 61 to 70 of about 2,099,317 (301)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Nordina: Nordic Studies in Science Education, 2015 English title: Norwegian master educations in natural science for lower secondary school – large differences in courses offered and size of master thesis Currently, the majority of students in lower secondary school teacher education take a four-year ...
Magne Olufsen +3 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Actively learning costly reward functions for reinforcement learning
Machine Learning: Science and TechnologyTransfer of recent advances in deep reinforcement learning to real-world applications is hindered by high data demands and thus low efficiency and scalability.
André Eberhard +4 more
doaj +1 more source
The development of MOOCs on students' learning outcomes in science subjects
Inovasi KurikulumEducational institutions may apply digital platforms to enhance the quality of learning, hence improving student outcomes through E-Learning, including Massive Open Online Courses (MOOCs). This study aims to develop Massive Open Online Courses (MOOCs) on
Nurhikmah H +4 more
doaj +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
RELIGION AND SCIENCE IN DIALOGUE: AN ASIAN CHRISTIAN VIEW
Zygon, 2016 We may understand natural science as part of the attempt by human beings to understand themselves and their place in the world in which they find themselves. In this sense, as Karl Rahner has suggested, natural science flows naturally into anthropology.
doaj +2 more sources
Current Status and Issues in Digital Archive in Natural History and Science and Technology.
, 2021 Tsuyoshi Hosoya
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source