Results 71 to 80 of about 5,749,580 (311)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
The development of MOOCs on students' learning outcomes in science subjects
Inovasi KurikulumEducational institutions may apply digital platforms to enhance the quality of learning, hence improving student outcomes through E-Learning, including Massive Open Online Courses (MOOCs). This study aims to develop Massive Open Online Courses (MOOCs) on
Nurhikmah H +4 more
doaj +1 more source
What if reality has no architecture? [PDF]
, 2011 The aim of this paper is to show that we can deny that reality is neatly segmented into natural kinds and still give a plausible view about what science is supposed to do – and the way science in fact works does not rely on the dubious metaphysical ...
Nanay, Bence
core
Emergent simplicity in microbial community assembly [PDF]
, 2018 Published in final edited form as: Science. 2018 August 03; 361(6401): 469–474. doi:10.1126/science.aat1168.A major unresolved question in microbiome research is whether the complex taxonomic architectures observed in surveys of natural communities can ...
Bajic, Djordje +8 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Global dynamics of a harmonically excited oscillator with a play : Numerical studies [PDF]
, 2017 This work was supported by the National Secretariat of Science, Technology and Innovation of Ecuador (SENESCYT); the Escuela Superior Politécnica del Litoral of Ecuador (ESPOL); the National Natural Science Foundation of China (11272268, 11572263) and ...
Chong, Antonio S. E. +3 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Knowledge Mobilization in the Beaver Hills Biosphere, Alberta, Canada
Land, 2020 This study explores how knowledge was and is mobilized to advance the objectives of the Beaver Hills Biosphere Reserve, located in Alberta, Canada. Established in 2016, a 12-year collaborative effort worked to establish the biosphere reserve and achieve ...
Clara-Jane Blye +3 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Methylmercury varies more than one order of magnitude in commercial European rice [PDF]
, 2017 P.M. thanks the Royal Thai Government for funding and C.C.B.
Brombach, Christoph-Cornelius +7 more
core +1 more source