Results 91 to 100 of about 2,187,661 (338)
Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences [PDF]
Molecules, 2011 Objects, goals, and main methods as well as perspectives of chemical biology are discussed. This review is focused on the fundamental aspects of this emerging field of life sciences: chemical space, the small molecule library and chemical sensibilization (small molecule microassays).
Vladimir V. Kouznetsov +2 more
openaire +3 more sources
Stephane Leduc and the vital exception in the Life Sciences
, 2016 Embryogenesis, the process by which an organism forms and develops, has long been and still is a major field of investigation in the natural sciences.
Clement, Raphael
core +2 more sources
Darwin and Fisher meet at biotech : on the potential of computational molecular evolution in industry [PDF]
, 2015 Today computational molecular evolution is a vibrant research field that benefits from the availability of large and complex new generation sequencing data - ranging from full genomes and proteomes to microbiomes, metabolomes and epigenomes.
Anisimova, Maria
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand
iScienceSummary: Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits.
Shuqing Tang +10 more
doaj +1 more source
Una filosofia per la neurofisiologia: Weizsacker e la forma dell'esperienza [PDF]
, 2015 The German doctor and physiologist Viktor von Weizsäcker believes philosophy is like an indispensable support for natural sciences, in particular for biology and neurophysiology.
RASINI, Vallori
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Межпредметные связи естественнонаучных дисциплин как способ формирования научного мировоззрения школьников [PDF]
, 2008 У статті розкрито важливість міжпредметних зв’язків природничих дисциплін (біологія, фізика, хімія) як засобу формування наукового світогляду школярів, що сприяє реалізації мети природничої освіти, функція якої формування у школярів цілісності знань про
Levashova, V. +2 more
core
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source