Results 101 to 110 of about 2,187,661 (338)

Organizational theory: With its applications in biology and ecology [PDF]

, 2013
Organizations are goal-directed entities which have been designed as deliberately structured and coordinated dynamic systems that connect with the external environment. Organizational theory is the study of structure, function and design of organization.
WenJun Zhang, Yue Zhao
core  

Physicalism and the Mind [PDF]

, 2014
This book addresses a tightly knit cluster of questions in the philosophy of mind. There is the question: Are mental properties identical with physical properties?
Francescotti, Robert
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 Omicron

iScience
Summary: Omicron has emerged as the most successful variant of SARS-CoV-2. In addition to mutations in Spike that mediate humoral immune escape, the Omicron-specific Envelope (E) T9I mutation has been associated with increased transmission fitness ...
Susanne Klute, Rayhane Nchioua, Arne Cordsmeier, Jyoti Vishwakarma, Lennart Koepke, Hala Alshammary, Christoph Jung, Maximilian Hirschenberger, Helene Hoenigsperger, Jana-Romana Fischer, Rinu Sivarajan, Fabian Zech, Steffen Stenger, Ruth Serra-Moreno, Ana Silvia Gonzalez-Reiche, Emilia Mia Sordillo, Harm van Bakel, Viviana Simon, Frank Kirchhoff, Timo Jacob, Dorota Kmiec, Andreas Pichlmair, Armin Ensser, Konstantin Maria Johannes Sparrer   +23 more
doaj   +1 more source

Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs [PDF]

, 2015
Disponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/ILs, as essential innate immune modulators, are involved in an array of biological processes.
Abrantes, J., Almeida, T., Costa, Paulo, de Matos, A.L., Esteves, P.J., Neves, F.   +5 more
core   +1 more source

The potential of leaf extract of Pangium edule Reinw as HIV-1 protease inhibitor: A computational biology approach

, 2020
Sefren Geiner Tumilaar1, Fatimawali Fatimawali1, Nurdjannah Jane Niode2, Yunus Effendi3, Rinaldi Idroes4, Ahmad Akroman Adam5, Ahmed Rakib6, Talha Bin Emran7, Trina Ekawati Tallei8* 1Pharmacy Study Program, Faculty of Mathematics and Natural Sciences ...
Tumilaar Sefren Geiner, Fatimawali Fatimawali, Niode Nurdjannah Jane, E. Yunus, Idroes Rinaldi, Adam Ahmad Akroman, Rakib Ahmed, Emran Talha Bin, Tallei Trina Ekawati   +8 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

In silico improvement of affinity for highly protective anti-malarial antibodies

iScience
Summary: The monoclonal antibody CIS43 preferentially binds the junctional region of Plasmodium falciparum circumsporozoite protein (PfCSP) and is highly protective in humans. Here, we develop an in silico pipeline to improve antigen-antibody interaction
Mateo Reveiz, Prabhanshu Tripathi, Lais Da Silva Pereira, Patience Kerubo Kiyuka, Tracy Liu, Yongping Yang, Baoshan Zhang, Dorra Benmohamed, Brian G. Bonilla, Carl W. Carruthers, Jr., Marlon Dillon, Daniel Gowetski, Sven Kratochvil, Gabriella Lagos, Mariah Lofgren, Ivan Loukinov, Shamika Mathis-Torres, Andrew J. Schaub, Elizabeth Scheideman, Arne Schön, Chen-Hsiang Shen, Yevel Flores-Garcia, Fidel Zavala, Facundo D. Batista, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Reda Rawi   +27 more
doaj   +1 more source

Males Under-Estimate Academic Performance of Their Female Peers in Undergraduate Biology Classrooms

PLoS ONE, 2016
Women who start college in one of the natural or physical sciences leave in greater proportions than their male peers. The reasons for this difference are complex, and one possible contributing factor is the social environment women experience in the ...
Daniel Z. Grunspan, Sarah L. Eddy, S. Brownell, Benjamin L. Wiggins, Alison J Crowe, S. Goodreau   +5 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source