Results 121 to 130 of about 2,187,661 (338)

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

iScience
Summary: Tissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating ...
Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combination therapy with alisertib enhances the anti-tumor immunity induced by a liver cancer vaccine

iScience
Summary: Alisertib is a potent aurora A kinase inhibitor in clinical trials for cancer treatment, but its efficacy on cancer vaccines remains unclear. Here, we developed a DNA vaccine targeting glypican-3 (pGPC3) and evaluated its efficacy with alisertib
Fang Xue, Jing Liu, Jinyan Wu, Xueer Li, Ningning Zhu, Shuting Tang, Mengli Zhang, Huan Duan, Rui Wang, Jing Zhang   +9 more
doaj   +1 more source

Intramolecular isotopic evidence for bacterial oxidation of propane in subsurface natural gas reservoirs

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Microorganisms can oxidize hydrocarbons anaerobically, but the detection and quantification of this process in natural settings remains difficult, impeding reliable estimation of these processes at the global scale.
A. Gilbert, B. Sherwood Lollar, F. Musat, T. Giunta, Song-Can Chen, Yuki Kajimoto, Keita Yamada, C. Boreham, N. Yoshida, Y. Ueno   +9 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Better Biology Teaching by Emphasizing Evolution & the Nature of Science

The American Biology Teacher, 1996
T EACHING about evolution in high school biology poses a pedagogical predicament for teachers: While on the one hand there is no idea more central to modern biology, nor any better supported, on the other hand there is in the popular (and student!) mind no topic more controversial in all of science. Despite the importance of evolution in modern science,
Martin K. Nickels, Craig E. Nelson
openaire   +1 more source

A stable backbone for the fungi [PDF]

, 2009
Fungi are abundant in the biosphere. They have fascinated mankind as far as written history goes and have considerably influenced our culture. In biotechnology, cell biology, genetics, and life sciences in general fungi constitute relevant model ...
Anne Kupczok, Arndt von Haeseler, Erika Kothe, Ingo Ebersberger, Kerstin Voigt, Martin Eckart, Matthias Gube, Sascha Strauss   +7 more
core   +1 more source

Authentic Inquiry through Modeling in Biology (AIM-Bio): An Introductory Laboratory Curriculum That Increases Undergraduates’ Scientific Agency and Skills

CBE - Life Sciences Education, 2018
Providing opportunities for science, technology, engineering, and mathematics undergraduates to engage in authentic scientific practices is likely to influence their view of science and may impact their decision to persist through graduation.
Susan D. Hester, M. Nadler, Jennifer Katcher, L. Elfring, Emily Dykstra, Lisa F. Rezende, M. Bolger   +6 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Cómo secuenciar los contenidos para la biología y geología de 4.º curso de la ESO [PDF]

, 2013
Según esta propuesta, la enseñanza de las ciencias de la naturaleza en secundaria obligatoria debe tratarse con un enfoque sistémico y holístico que permita la integración de la biología y la geología para asegurar aprendizajes significativos, en ...
Morón Monge, Hortensia, Morón Monge, María del Carmen, Wamba Aguado, Ana Mª   +2 more
core