Results 141 to 150 of about 2,187,661 (338)

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

iScience
Summary: Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated ...
Josephine Carpentier, Marta Freitas, Valle Morales, Katiuscia Bianchi, John Bomalaski, Peter Szlosarek, Sarah A. Martin   +6 more
doaj   +1 more source

Az evolúciós elv és a létezők hierarchiája : Illeszkedik-e egymáshoz a természettudományok evolúciós elve és a létezők hierarchiájának eszméje? [PDF]

, 2016
Today, the evolution paradigm encompasses the science of biology and is also the guiding principle to our entire scientific world view. It is essential for understanding the achievements of modern phylogenetic taxonomy including most of the biological ...
Bagyinszki, Péter Ágoston, Mészáros, Lukács   +1 more
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Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

iScience
Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells.
Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb   +13 more
doaj   +1 more source

Comparison of Physics, Chemistry, and Biology Teachers’ Perceptions of Nature of Science and Domains of Science

Science & Education
The paper presents an empirical study on physics, chemistry, and biology teachers’ perceptions of nature of science (NOS) and domains of science. Family Resemblance Approach to NOS (FRA) was used as a theoretical framework and informed the data analysis approaches.
Kaya, E, Erduran, S
openaire   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma

iScience
Summary: We previously demonstrated that RNA helicase DDX3X (DDX3) can be a therapeutic target in Ewing sarcoma (EWS), but its role in EWS biology remains unclear. The present work demonstrates that DDX3 plays a unique role in DNA damage repair (DDR). We
Matthew E. Randolph, Marwa Afifi, Aparna Gorthi, Rachel Weil, Breelyn A. Wilky, Joshua Weinreb, Paul Ciero, Natalie ter Hoeve, Paul J. van Diest, Venu Raman, Alexander J.R. Bishop, David M. Loeb   +11 more
doaj   +1 more source

The Nature of Science & the Next Generation of Biology Education

The American Biology Teacher, 2015
The nature of science (NOS) is an often neglected part of science teaching, yet it provides a vital background for students, detailing how science and scientists work and how scientific knowledge is created, validated, and influenced. Here, I review the concept of NOS and some of the challenges to its inclusion in science classes.
openaire   +1 more source

Human nature and institutional analysis [PDF]

This essay reviews some findings in cognition sciences and examines their consequences for the analysis of institutions. It starts by exploring how humans’ specialization in producing knowledge ensures our success in dominating the environment but also ...
Benito Arruñada
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