Results 151 to 160 of about 2,187,661 (338)

Natural language and the genetic code: from the semiotic analogy to biolinguistics [PDF]

, 2012
[Abstract] With the discovery of the DNA structure (Watson and Crick, 1953), the idea of DNA as a linguistic code arose (Monod, 1970). Many researchers have considered DNA as a language, pointing out the semiotic parallelism between genetic code and ...
Bel Enguix, Gemma, Jiménez López, M. Dolores   +1 more
core  

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression

iScience
Summary: Transforming growth factor β (TGF-β) is abundantly present in the tumor microenvironment, contributing to cancer progression. However, the regulatory mechanism by which TGF-β affects vascular endothelial cells (ECs) in the tumor microenvironment
Kako Hanada, Yuki Saito, Takahiro Takagi, Mitsuki Go, Yota Nakano, Toshihiko Inagawa, Hideyo Hirai, Marcus Fruttiger, Susumu Itoh, Fumiko Itoh   +9 more
doaj   +1 more source

Enhancement of Science Students\u27 Process Skills Through Implementation of Green Learning Method (GeLem) with Conservation-Based Inquiry Approach [PDF]

, 2017
The inquiry of science teaching aims to encourage the ability to think, work and be scientific and communicate as an important aspect of life skills.
Ardhi, M. W. (M), Putra, P. D. (P), Savitri, E. N. (E), Wusqo, I. U. (I)   +3 more
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma

iScience
Summary: Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic TP53 mutation and increased risk of cancer development, including Sonic Hedgehog-activated medulloblastoma (SHH-MB).
Anna S. Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty, Jürgen Burhenne, Shunya Ohmura, Tim Holland-Letz, Lena M. Kutscher, Aurélie Ernst, Pei-Chi Wei, Thomas G.P. Grünewald, Ina Oehme, Marcel Kool, David T.W. Jones, Kristian W. Pajtler, Christian P. Kratz, Stefan M. Pfister, Olaf Witt, Till Milde   +24 more
doaj   +1 more source

Aplikasi Mulsa Imperata Cylindrica (L.), Mucuna Bracteata Dc. Dan Kompos Pelepah Kelapa Sawit (Elaeis Guineensis Jacq.), Terhadap Perkecambahan Dan Pertumbuhan Mikania Micrantha H.b.k. [PDF]

, 2014
The research on the use of mulch of Imperata cylindrica, Mucuna bracteata, and palm midrib compost on the germination and growth of Mikania micrantha had been conducted at the Laboratory of Biology and Botany Gardens, Department of Biology, Faculty of
Fatonah, S. (Siti), Herman, H. (Herman), Malinda, S. (Sari)   +2 more
core  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

CD28 signaling domain boosts persistence and in vivo anti-tumor activity of stem cell-derived CD19-CAR-NK cells

iScience
Summary: Allogeneic natural killer (NK) cell-based therapies with an outstanding safety profile, are a compelling alternative to autologous T cell-based approaches for cancer immunotherapy, offering innate tumor-killing ability that can be further ...
Nina Kok, Didem Ozkazanc, Amanda A. van Vliet, Danielle Steenmans, Simar Pal Singh, Tolga Sutlu, Anna-Maria Georgoudaki, Monica Raimo, Jan Spanholtz, Adil Doganay Duru   +9 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source