Results 71 to 80 of about 2,187,661 (338)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A limit to sustained performance constrains trill length in birdsong
iScience, 2023 Summary: In birds, song performance determines the outcome of contests over crucial resources. We hypothesized that 1) sustained performance is limited within song, resulting in a performance decline towards the end and 2) the impact of song length is ...
Javier Sierro +2 more
doaj +1 more source
PeerJ, 2014 Despite women earning similar numbers of graduate degrees as men in STEM disciplines, they are underrepresented in upper level positions in both academia and industry.
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Polo-like kinase 4: A molecular linchpin in cancer and its management
iScienceSummary: Genomic instability and cell cycle dysregulation are considered hallmarks of cancer. Polo-like kinase 4 (PLK4), a member of the PLK family, is essential for faithful centriole duplication, which, when dysregulated, contributes to genomic ...
Durdana Muntaqua +3 more
doaj +1 more source
A Classification of the Projective Lines over Small Rings [PDF]
, 2006 A compact classification of the projective lines defined over (commutative) rings (with unity) of all orders up to thirty-one is given. There are altogether sixty-five different types of them.
Kibler, Maurice +3 more
core +4 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Is this worth the trouble? Strategic conflict management in Tonkean macaques
iScience, 2023 Summary: Conflict management entails preventing and repairing damages resulting from social conflicts. While previous research has emphasized post-conflict actions like reconciliation, the understanding of how primates weigh the costs and benefits of ...
Sébastien Ballesta, Hélène Meunier
doaj +1 more source
, 2015 In this essay, I argue that mathematics is a natural science---just like physics, chemistry, or biology---and that this can explain the alleged "unreasonable" effectiveness of mathematics in the physical sciences.
E. Landry +4 more
core +1 more source
Measure-valued limits of interacting particle systems with k-nary interactions. II, Finite-dimensional limits [PDF]
, 2004 It is shown that Markov chains in Z+d describing k-nary interacting particles of d different types approximate (in the continuous state limit) Markov processes on R+d having pseudo-differential generators p (x,i (/x)) with symbols p (x,) depending ...
Kolokoltsov, V. N. (Vasiliĭ Nikitich)
core +1 more source