Results 121 to 130 of about 5,782,691 (288)

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. [PDF]

Nat Chem Biol, 2018
Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN, Shen B.   +10 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Phytochemical Profiling by HPLC-DAD, GC-MS, and ICP-OES and Bioactive Potential of Salsola kali L.: Structural Elucidation and ADME/T Evaluation for Pharmacological Insights

Journal of Chemistry
Salsola kali L., a halophytic plant renowned for its resilience in arid and saline environments, possesses a rich and diverse phytochemical profile with significant bioactive potential.
Haichour Rima, Badis Aouzal, Hamdi Bendif, Mehmet Öztürk, Gulin Gumusbulut Sener, Fehmi Boufahja, Khellaf Rebbas, Elfalleh Walid, Susana Rodríguez Couto, Stefania Garzoli   +9 more
doaj   +1 more source

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl, Marika C. Möller, Lindsay Wilson, Anne Vik, Toril Skandsen, Jonas Stenberg, CENTER‐TBI participants and investigators   +6 more
wiley   +1 more source

Recent Advances in Advanced Membrane Materials for Natural Gas Purification: A Review of Material Design and Separation Mechanisms

Membranes
Natural gas plays a pivotal role in the global energy landscape under the dual challenges of energy transition and climate change. However, the impurities present within natural gas pose several disadvantages, including corrosion of transportation ...
Qijie Fan, Rui Xiao, Cheng Yang, Meixuan Xin, Xia Zheng, Guangyong Zeng   +5 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Study on Separation Performance of Hydrocyclone with Built-in Twisted Band

Shiyou jixie, 2019
In the process of separating natural gas hydrate silt mixed slurry, the unstable external conditions often result in the decomposition of natural gas from hydrate slurry in conventional hydrocyclone.
Sun Yi, Rao Yongchao, Li Lijun, Wang Shuli, Wang Ziwen, Ding Boyang   +5 more
doaj  

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

Bulletin of the American Museum of Natural History.

, 1881
Comprises articles on geology, paleontology, mammalogy, ornithology, entomology and anthropology.Mode of access: Internet.Beginning with v. 23, information on anthropological matter continued in: Anthropological papers of the American Museum of Natural ...
American Museum of Natural History.
core  

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source