Results 211 to 220 of about 333,618 (331)

Evaluation of a modified triple‐combination anesthesia using dexmedetomidine in mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Development of a modified ketamine‐free anesthetic (dMMB) using dexmedetomidine. To improve the safety and recovery profile of conventional MMB, we developed dMMB by replacing medetomidine with dexmedetomidine. This ketamine‐free formulation showed comparable anesthetic depth and enhanced thermoregulation, avoiding unnecessary isomers for safer use ...
Masaki Watanabe   +5 more
wiley   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li   +9 more
wiley   +1 more source

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang   +8 more
wiley   +1 more source

A ventilation performance experiment of the natural ventilation residence using a visualization wind tunnel

open access: diamond, 2006
近藤 明   +7 more
openalex   +2 more sources

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

open access: yesAnalysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann   +5 more
wiley   +1 more source

Mechanistic Insights Into Cellulose Dissolution in Solvents for Advanced Industrial Applications: A Systematic and Bibliometric Review

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Cellulose dissolution is important for various industries, including textiles, bioplastics, foods and pharmaceuticals, yet achieving efficient dissolution remains challenging. Deep eutectic solvents (DES) have emerged as promising alternatives to traditional solvents due to their low toxicity, biodegradability and sustainability.
Chigozie Charity Okwuwa   +4 more
wiley   +1 more source

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