Results 31 to 40 of about 114,377 (311)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Development and verification of a new natural ventilation system for offices utilizing low-temperature outdoor [PDF]

E3S Web of Conferences
In recent years, due to seasonal changes in Japan, summers and winters have become longer and springs and autumns shorter. As a result, opportunities to utilize natural ventilation, one of the energy-saving methods for air conditioning, have decreased ...
Fujii Takuro, Tanaka Hiroaki, Yamanaka Toshio, Kobayashi Tomohiro, Momoi Toshihisa, Choi Narae, Wakasa Miho   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Natural Ventilation for Cooling Energy Saving: Typical Case of Public Building Design Optimization in Guangzhou, China

Applied Sciences
Heating ventilation and air conditioning systems account for over one-third of building energy usage, especially for public buildings, due to large indoor heat sources and high ventilation and thermal comfort requirements compared to residential ...
Menglong Zhang, Wenyang Han, Yufei He, Jianwu Xiong, Yin Zhang   +4 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Design of a Natural Ventilation System in the Dunhuang Museum [PDF]

, 2006
Fresh air and good air quality can be obtained by a natural ventilation system, to fulfill the requirement of near natural conditions for the psychological health of mankind.
Guan, W., Zhang, Y.
core  

The potential effects of window configuration and interior layout on natural ventilation buildings: A comprehensive review

Cleaner Engineering and Technology
Natural ventilation is an eco-friendly and renewable energy source that enhances thermal comfort and energy efficiency. The window is the most traditional method of introducing natural ventilation into the built environment, but its full potential has ...
Xin Yin, Mohammed W. Muhieldeen, Ruzaimah Razman, Jonathan Yong Chung Ee, Meng Choung Chiong   +4 more
doaj   +1 more source

Investigation of the Energy Saving Efficiency of a Natural Ventilation Strategy in a Multistory School Building

Energies, 2020
Under-ventilation and high energy consumption are some of the problems associated with school classrooms. Thus, it is necessary to develop a ventilation strategy that is characterized by high energy-saving and ventilation efficiency.
Beungyong Park, Sihwan Lee
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Experimental Investigation of Natural Ventilation Rates in a Domestic House in Laboratory Conditions [PDF]

Stack-driven ventilation is one of the key forms of natural ventilation. Yet, it has rarely been tested at full scale, even though such studies offer critical evidence for validating simplified theoretical models.
Fateri, Sara, Henshaw, Grant, Swan, William, Fitton, Richard, Jankovic, Ljubomir   +4 more
core   +2 more sources