Results 61 to 70 of about 98,175 (244)

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

open access: yesAdvanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng   +20 more
wiley   +1 more source

Theoretical simulation of natural air exchange and indoor air quality with an example of a green wall introduction

open access: yesResults in Engineering
Nowadays, most modern buildings have mechanical ventilation with heat recovery. But old buildings are equipped with natural ones. Some modern houses are equipped with automatic window control to save energy. Therefore, natural ventilation is topical.
Viktor Mileikovskyi   +2 more
doaj   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

open access: yesAdvanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su   +15 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

Natural balanced ventilation. Simulations part 2

open access: yesE3S Web of Conferences, 2018
The paper is devoted to test results of air flow through natural ventilation supply-exhaust ducts in the rooms located on the upper floor of the building that were conducted in ANSYS Fluent software.
Gaczoł Tomasz
doaj   +1 more source

Evaluation of Different Natural Ventilation Strategies by Monitoring the Indoor Air Quality Using CO2 Sensors. [PDF]

open access: yesInt J Environ Res Public Health, 2023
Sánchez-Fernández A   +3 more
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Occupants’ Utilization of Natural Ventilation: A Study of Selected Terrace House Designs in Hot-humid Climate

open access: yesInternational Journal of Built Environment and Sustainability, 2015
With increased time spent indoors and demand for enhanced comfort levels, energy consumption in homes is rising mostly for cooling, particularly in hot-humid regions.
Ibiyeye AI, Zalina Shari, Mohd FZ Jafaar
doaj   +1 more source

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