Results 1 to 10 of about 699,210 (251)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Time in and for nature-based solutions. No quick fix solutions for complex ecological and social processes

Nature-Based Solutions
Nature-based solutions (NbS) are an increasingly widespread tool in environment and development policies. They embody the idea that nature and natural processes can be purposefully used by humans to provide solutions to pressing environmental and social ...
Ina Lehmann, Julia Grosinger, Steffen Bauer, Jean Carlo Rodríguez de Francisco, Katarzyna Negacz, Jonas Hein   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effect of compost and compost-derived biochar on the growth of lettuce irrigated with water and treated wastewater

Nature-Based Solutions
As climate change keeps progressing, the use of biochar and compost as nature-based materials emerges as sustainable alternative that can have a positive impact on agriculture.
Panagiotis Regkouzas, Nancy Katie, Konstantinos Bontiotis, Alexandros Stefanakis   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Connecting the dots: tracing the origins of 2015 equatorial Southeast Asian fires

Environmental Research Letters
Tropical landscapes in Southeast Asia are susceptible to the detrimental consequences of fires. However, investigations on ignition sources in the region are limited despite its importance in formulating prevention strategies. We addressed this gap using
Adrian Dwiputra, Ping Yowargana, Janice S H Lee, Hoong Chen Teo, Zu Dienle Tan, Yiwen Zeng, Andrey Krasovskiy, Lian Pin Koh   +7 more
doaj   +1 more source

Advancing blue-green infrastructure design with synthetic 3D drainage channels: A scenario-based flood model in Nova Scotia, Canada

Nature-Based Solutions
Urbanized riverscapes are facing challenges due to hydrological changes. Adjusted flow regimes and imperviousness are contributing to increased flood risks resulting from gray infrastructure and strained subgrade drainage systems.
Corey Dawson
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A scenario-based analysis of wetlands as nature-based solutions for flood risk mitigation using the TELEMAC-2D model

Nature-Based Solutions
Urban flooding is an escalating threat in rapidly urbanising regions, particularly in sub-Saharan Africa (SSA), where unregulated expansion and climate change intensify risks.
Kirk B. Enu, Fabian Merk, Hao Su, Manuel Rauch, Aude Zingraff-Hamed, Karl Broich, Kristian Förster, Stephan Pauleit, Markus Disse   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source