Results 91 to 100 of about 19,240,983 (413)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
THE NATURE, PREVENTION, AND TREATMENT OF HEAT HYPERPYREXIA: THE CLINICAL ASPECT [PDF]
, 1920 William Willcox
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Mapping forest-based natural climate solutions
Communications Earth & EnvironmentNatural climate solutions are critical actions of ecosystem stewardship to mitigate climate change. However, prioritizing locations and possible actions is challenging.
Colin S. Shanley +6 more
doaj +1 more source
Natural reward as the fundamental macroevolutionary force [PDF]
arXiv, 2019 Darwin's theory of evolution by natural selection does not predict long-term progress or advancement, nor does it provide a useful way to define or understand these concepts. Nevertheless, the history of life is marked by major trends that appear progressive, and seemingly more advanced forms of life have appeared.
arxiv
STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES [PDF]
, 1944 Oswald T. Avery +2 more
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Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Naturalness and Naturalness Criteria [PDF]
arXiv, 2005 We analysis how to describe the level of naturalness and pointed out that Barbieri and Giudice's the widely adopted sensitivity criteria of naturalness can not reflect the level of naturalness correctly, we analysis the problems of the sensitivity criteria and proposed a new criterion that can solve these problems, and also give a clear physical ...
arxiv
The Nature of the Chemical Bond and the Structure of Molecules and Crystals [PDF]
, 1941 openalex +1 more source
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source