Results 51 to 60 of about 17,289,524 (339)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Author insights 2015 survey [PDF]
The annual Author Insights Survey, run by Nature Publishing Group (NPG) and sister company Palgrave Macmillan forms part of a wider research programme which aims to understand general author attitudes and behaviours around publishing, to track any ...
Nature Publishing Group +1 more
core
Review: The nature of wishing [PDF]
, 2006 Review of the dance: The Nature of ...
Cheesman, Sue
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The nature of gravitational singularities
, 2004 The nature of gravitational singularities, long mysterious, has now become clear through a combination of mathematical and numerical analysis. As the singularity is approached, the time derivative terms in the field equations dominate, and the ...
Berger B., DAVID GARFINKLE, Uggla C.
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The nature of spacetime singularities
, 2005 Present knowledge about the nature of spacetime singularities in the context of classical general relativity is surveyed. The status of the BKL picture of cosmological singularities and its relevance to the cosmic censorship hypothesis are discussed.
Rendall, Alan D.
core +2 more sources
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature [PDF]
, 2016 Jeffrey I. Boucher +2 more
openalex +1 more source