Results 81 to 90 of about 9,516,581 (298)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Critical Behavior of the Sandpile Model as a Self-Organized Branching Process
, 1996 Kinetic equations, which explicitly take into account the branching nature of sandpile avalanches, are derived. The dynamics of the sandpile model is described by the generating functions of a branching process.
A. Erzan +12 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Explicating explicit reflection in nature of science education: a systematic literature review
Frontiers in EducationFor over two decades, “explicit reflection” has been a cornerstone concept in Nature of Science education. Many studies underscore the crucial role of Explicit Reflection in effective Nature of Science education, yet its ubiquity is accompanied by ...
Lotte Boven +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Dialectic of the Nature-Society-System
tripleC: Communication, Capitalism & Critique, 2008 There are four logical possibilities for conceiving the relationship of nature and society: the reduction of society to nature, the projection of nature into society, dualism, and a nature-society-dialectic. This differentiation results in four different
Christian Fuchs
doaj +1 more source
A general theory for preferential sampling in environmental networks
, 2019 This paper presents a general model framework for detecting the preferential sampling of environmental monitors recording an environmental process across space and/or time.
Shaddick, Gavin +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Abordagem dimensional em psiquiatria e filosofia do processo: notas preliminares
Psicopatologia Fenomenológica Contemporânea, 2019 Dimensional psychopathology and process philosophy form together a potentially fruitful research field in psychiatry and philosophy. The continuum of mental disorders and the tradition of unitary psychosis might profit from process metaphysics, which ...
Mauricio Viotti Daker
doaj +1 more source