Results 71 to 80 of about 4,554,835 (278)

Examining the connection between nature connectedness and dark personality [PDF]

, 2020
The psychological construct of nature connectedness - the depth of an individual's relationship with the natural world - has not only been associated with benefits for mental well-being but has also shown relationships with personality traits relevant to
Richardson, Miles, Philip Clarke, Dominic Petronzi, Petronzi, D., Miles Richardson, Clarke, P., Alice Rees, Richardson, M., Petronzi, Dominic, Fido, Dean, Fido, D., Dean Fido, Rees, A., Rees, Alice, Clarke, Philip   +14 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Participatory collective farming as a leverage point for fostering human-nature connectedness

Ecosystems and People, 2021
Human-nature connectedness is key to foster environmental and socio-cultural sustainability in agricultural landscapes since it promotes the establishment of belonging, stewardship, and connections to nature.
Irene Pérez-Ramírez, Marina García-Llorente, Clara Saban de la Portilla, Alejandro Benito, Antonio J. Castro   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Investigating the relationship between nature exposure, nature connectedness and wellbeing in individuals with cancer

Prior quantitative research has highlighted the benefits that nature brings to the well-being of cancer survivors. Here, an Interpretative phenomenological analysis was adopted to investigate the relationship between nature exposure, nature connectedness
Haughton, Melanie, Kotera, Yasuhiro, Quah, A, Quah, Amanda, Haughton, M., Kotera, Y.   +5 more
core   +1 more source

The Relationship Between Nature Connectedness and Eudaimonic Well-Being: A Meta-analysis [PDF]

, 2019
Nature connectedness relates to an individual’s subjective sense of their relationship with the natural world. A recent meta-analysis has found that people who are more connected to nature also tend to have higher levels of self-reported hedonic well ...
Alison Pritchard, Miles Richardson, David Sheffield, Kirsten McEwan   +3 more
core   +1 more source

experiences to foster nature connectedness through head, heart and hand

, 2022
Human activities continue to inflict profound detrimental impacts on biodiversity, yet we have not observed a commensurate shift in people's mindsets to achieve a more harmonious relationship between people and nature.
Luis Mata, Beer, Tanja, Renowden, Christina, Christina Renowden, Tanja Beer, Mata, Luis   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source