Results 161 to 170 of about 181,914,409 (290)

The nature of science in Chinese senior secondary geography textbooks under the context of sustainable development: Identifying the gaps and seeking reform. [PDF]

PLoS One
Zhang W, Wang X, Wu C, Dong C.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Nature Meets Science: The Role of Food-Grade Oils and Green Excipients in Pharmaceutical Nanoemulsion Formulation. [PDF]

Materials (Basel)
Villapiano F, Capuano M, D'Aria F, Giancola C, Campani V, De Rosa G, Biondi M, Mayol L.   +7 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The nature of science is inclusive: A qualitative study of LGBTQ+ undergraduate STEM students' experiences in pursuing planetary sciences. [PDF]

Anal Soc Issues Public Policy
Stage MA, Carvalho OD, Ruben MA.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Engaging short film activity that supports learning, science identity, and nature of science comprehension. [PDF]

J Microbiol Biol Educ
Molder AL, Howell E, Goodwin S, Behrman S, Mathews S.   +4 more
europepmc   +1 more source

Proceedings of the Arizona-Nevada Academy of Science, Volume 16 (1981)

, 1981
TWENTY FIFTH ANNUAL MEETING / May 1-2, 1981 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / Participating Societies: Arizona Junior Academy of Science, American Water Resources Association, Arizona ...
Arizona-Nevada Academy of Science
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pursue the nature of science: Advocate for a better research environment. [PDF]

Innovation (Camb)
Dai J.
europepmc   +1 more source