Results 91 to 100 of about 704,912 (357)

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Betahistine as an add-on: The magic bullet for postoperative nausea, vomiting and dizziness after middle ear surgery?

Journal of Anaesthesiology Clinical Pharmacology, 2013
Purpose: Patients undergoing middle ear surgery experience variable degrees of postoperative nausea and vomiting (PONV) despite prophylaxis and treatment with ondansetron or other 5HT 3 receptor antagonists.
Sandip Mukhopadhyay, Mausumi Niyogi, Ritam Ray, Basabdatta Samanta Mukhopadhyay, Manotosh Dutta, Monoj Mukherjee   +5 more
doaj   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting

Drug Design, Development and Therapy, 2021
Motoyasu Kato,1 Shinichi Sasaki,1,2 Misa Tateyama,1 Yuta Arai,1 Hiroaki Motomura,1 Issei Sumiyoshi,1 Yusuke Ochi,1 Junko Watanabe,1 Hiroaki Ihara,1 Shinsaku Togo,1 Kazuhisa Takahashi1 1Department of Respiratory Medicine, Juntendo University Graduate ...
Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K   +10 more
doaj  

To evaluate the effects of acupressure by sea band on nausea and Vomiting of pregnancy [PDF]

: Nausea and Vomiting are the most common disorders of digestive system in the pregnancy. This is a clinical intervention study. Main object was to evaluate the effects of acupressure in reducing the severity of nausea and vomiting in primigravida ...
خاوندی زاده اقدم, سیما, کاظم زاده, رأفت   +1 more
core  

Serum thyroid hormone level in women with nausea and vomiting in early pregnancy

, 2008
The aim of this study was to establish the relationship between the serum Thyroid Stimulating Hormone (TSH) and thyroxin (T4) which reflect thyroid function assessment, with nausea and vomiting, among pregnant women in early pregnancy.
Mansourian, A.R., Mansourian, H.R., Shahmohammdi, F.   +2 more
core   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Acupressure to Reduce Treatment-Related Symptoms for Children With Cancer and Recipients of Hematopoietic Stem Cell Transplant: Protocol for a Randomized Controlled Trial. [PDF]

, 2019
BackgroundWe describe the study design and protocol of a pragmatic randomized controlled trial (RCT) Acupressure for Children in Treatment for a Childhood Cancer (ACT-CC).ObjectiveTo describe the feasibility and effectiveness of an acupressure ...
Adcock, Robyn, Banerjee, Anu, Dvorak, Christopher C, Golden, Carla, Hartogensis, Wendy, Hecht, Frederick M, Hu, Hiroe, Lown, E Anne, Mangurian, Christina, Melton, Alexis, Morgan, Michael, Shear, Deborah, Vittinghoff, Eric   +12 more
core   +1 more source