Results 181 to 190 of about 704,912 (357)

Comparison of Ropivacaine and Bupivacaine on Analgesia Quality and Incidence of Nausea and Vomiting in Patients Undergoing Nephrolithotripsy with Spinal Anesthesia: A Randomized Double-Blind Clinical Trial [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Nowadays, intraspinal anesthesia is widely used as the method of choice for many nephrolithotripsy surgeries. Postoperative pain management remains one of the primary concerns for anesthesiologists.
Fatemeh Eftekharian, Fatemeh Zahabi, Ahmad Rastgarian, Navid Kalani, Reza Sahraei   +4 more
doaj  

Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients [PDF]

, 1992
Corey S. Scher, David Amar, Robert H. McDowall, Samuel Barst   +3 more
openalex   +1 more source

Sensory conflict in motion sickness: An observer theory approach [PDF]

Motion sickness is the general term describing a group of common nausea syndromes originally attributed to motion-induced cerebral ischemia, stimulation of abdominal organ afferent, or overstimulation of the vestibular organs of the inner ear. Sea-, car-,
Oman, Charles M.
core   +1 more source

First‐in‐Human Study of Merotocin, a Short‐Acting Peptidic Oxytocin Receptor Agonist for Lactation Support

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Endogenous oxytocin plays an important role in lactation, but its effectiveness as an exogenous galactagogue has been modest due to dose‐limiting side effects related to off‐target effects at the vasopressin V2 receptor. Merotocin (FE 202767) is a short‐acting peptidic oxytocin receptor agonist with the potential to aid mothers experiencing ...
Yu Bagger, Carina Holmqvist, Daniël M. Jonker, Bjarke M. Klein, Lorien E. Urban   +4 more
wiley   +1 more source

Chlorpromazine, placebo and droperidol in the treatment of nausea and vomiting associated with cisplatin therapy

, 1983
R. Stuart‐Harris, Robert Buckman, I.D. Starke, E. Wiltshaw   +3 more
openalex   +1 more source

Relative Bioavailability, Food Effect, and Bioequivalence Studies to Assess a New Zanubrutinib 160‐mg Tablet: Results From 2 Phase 1 Studies in Healthy Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Zanubrutinib is a next‐generation Bruton tyrosine kinase inhibitor approved for treating B‐cell malignancies. Two phase 1 studies evaluated a new 160‐mg zanubrutinib tablet versus 80‐mg capsules. In study BGB‐3111‐115 (n = 43), a randomized 3‐period crossover trial, relative bioavailability and food effects were assessed.
Bilal Tariq, Chester Lin, Vaibhav Mundra, Yang Gao, Dan Zhang, Ying C. Ou   +5 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In total, 272 participants were randomized 3:1 to a single intravenous dose of 600 mg AZD7442 or placebo and
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Haiyue Zhang, Yunfei Li, Cecil Chi‐Keung Chen, Oleg Stepanov, Weifeng Tang, Wenhong Zhang   +10 more
wiley   +1 more source

A1245 NITROUS OXIDE DOES NOT INCREASE POSTOPERATIVE NAUSEA/VOMITING IN PEDIATRIC OUTPATIENTS UNDERGOING TONSIIXECTOMY-ADENOIDECTOMY [PDF]

, 1990
Uma A. Pandit, S Pryn, Gail I. Randel, L Lévy, Ian Lewis   +4 more
openalex   +1 more source

Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Galcanezumab is used in several regions, including the United States, Europe, and China, as a preventive treatment for migraine. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PK) of galcanezumab in healthy Chinese participants.
Jingjing Wang, Nanyang Li, Jinjie He, Jing Zhang, Lili Wang, William Kielbasa, Chenxi Qian, Yanjie Zhang, Liang Wang   +8 more
wiley   +1 more source