Results 211 to 220 of about 704,912 (357)

PREVENTION OF POST-OPERATIVE NAUSEA AND VOMITING BY HALOPERIDOL OR DROPERIDOL

, 1990
William T. Ross, J. A. Franz
openalex   +1 more source

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, EarlyView.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Efficacy of paravertebral block on postoperative nausea and vomiting: a meta-analysis of randomized controlled trial. [PDF]

BMC Anesthesiol
Zeng J, Cao Q, Hong A, Gu Z, Jian J, Liang X.   +5 more
europepmc   +1 more source

UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Sacituzumab govitecan (SG), a humanized antibody‐drug conjugate, enables intra‐tumor delivery of SN‐38, the active metabolite of irinotecan, with the aim of increasing efficacy. SN‐38 is predominantly inactivated by the polymorphically expressed uridine diphosphate glucuronosyltransferase 1A1 (UGT1AA) where reduced activity can lead to toxicity.
Cinzia Dello Russo, Innocent Gerald Asiimwe, Sudeep Pushpakom, Carlo Palmieri, Munir Pirmohamed   +4 more
wiley   +1 more source

Does adding ginger extract to a preoperative carbohydrate drink improve outcomes in enhanced recovery after elective neuro-oncologic craniotomy? A randomized controlled trial. [PDF]

Front Nutr
Kaewborisutsakul A, Kitsiripant C, Churuangsuk C, Puttarak P, Suntornlohanakul O, Khanungwanitkul K, Rattanaburi A, Uppanisakorn S, Sungkaro K, Taweesomboonyat C, Tunthanathip T, Oearsakul T, Sae-Heng S.   +12 more
europepmc   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi, Cole Cornwell, Kyunghee Yang, Paul M. Beringer   +3 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Isolated Gastric Crohn's Disease. [PDF]

ACG Case Rep J
Udine M, Rodriguez A, Tirath A, Iskandar H.   +3 more
europepmc   +1 more source

The Effect of Midazolam on Persistent Postoperative Nausea and Vomiting [PDF]

, 1999
Tullio Florio, Roger Goucke
openalex   +1 more source

1,5‐Diisocyanonaphthalene: The Lowest Molecular Weight Fluorescent Probe for the Determination of Trace Amounts of Sulfoxides in Both Organic and Aqueous Media

ChemPhotoChem, EarlyView.
We present 1,5‐DIN as a low‐cost, efficient fluorescent probe for trace DMSO detection in organic and aqueous media. It shows strong quenching, with LODs from 5–50 ppm, even in complex matrices. Theoretical insights support its mechanism, highlighting its promise for practical applications.
Attila Kovács, Rajmond Schiwert, Péter Kun, Zoltán Mucsi, László Vanyorek, Béla Viskolcz, Miklós Nagy   +6 more
wiley   +1 more source