Results 171 to 180 of about 147,413 (282)

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Compact, reconfigurable, and scalable photonic neurons by modulation-and-weighting microring resonators. [PDF]

eLight
Zhang W, Wang Y, Lederman JC, Shastri BJ, Prucnal PR.   +4 more
europepmc   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

Order parameters and phase transitions of continual learning in deep neural networks. [PDF]

Proc Natl Acad Sci U S A
Shan H, Li Q, Sompolinsky H.
europepmc   +1 more source

The Political Economy of Emergency: Postcolonialism, Crisis Governance and Decolonial Alternatives

Journal of Law and Society, EarlyView.
Abstract The political rhetoric surrounding the Horn of Africa is perpetually framed through narratives of crisis, tragedy and emergency. These labels, rather than simply being used to describe instability, function as tools of governance to normalise dysfunction and entrench cycles of dependency.
HOPE JOHNSON
wiley   +1 more source

Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model. [PDF]

iScience
Yu Y, Du J, Li B, Cheng Y, Lin F, Zhou J, Song Y, Liu C, Cai S.   +8 more
europepmc   +1 more source

VERNALIZATION2 alters early tiller development in a facultative spring hexaploid bread wheat

New Phytologist, EarlyView.
Summary An extended period of cold exposure enables the process of vernalization in winter cereals and is important for the synchronised timing of the floral transition. The cereal‐specific floral repressor VERNALIZATION2 (VRN2) has an integral role in vernalization, yet this locus remains poorly characterised in facultative spring hexaploid wheat ...
Dominique Hirsz, Harry Taylor, India Lacey, Wenxue Wu, Adam Gauley, Laura Dixon   +5 more
wiley   +1 more source

Construction and validation of deep learning-based pathomics signature model for predicting postoperative recurrence of patients with clear cell renal cell carcinoma. [PDF]

Am J Cancer Res
Yang Y, Li J, Gao Y, Liu W, Zhu B, Ding J, Wang L, Shi X, Zhang W.   +8 more
europepmc   +1 more source

Independent Multicentre Validation of the ‘Six‐Point’ Model for Malignant Transformation Risk in Oral Epithelial Dysplasia

Oral Diseases, EarlyView.
ABSTRACT Background Histological grading of oral epithelial dysplasia (OED) is used for predicting malignant transformation risk. However, grading is associated with significant subjectivity and observer variability leading to inconsistency in prognosis prediction.
Hanya Mahmood, Mike Bradburn, Nadim M. Islam, Omar Kujan, Nasir Rajpoot, Alan Roger Santos‐Silva, Pablo Agustin Vargas, Jacqueline James, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram   +10 more
wiley   +1 more source

Generative AI for navigating synthesizable chemical space. [PDF]

Proc Natl Acad Sci U S A
Gao W, Luo S, Coley CW.
europepmc   +1 more source