Results 111 to 120 of about 36,134 (309)

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

open access: yesiMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang   +72 more
wiley   +1 more source

Discussion on Current Topics in Naval Aviation Medicine

open access: green, 1959
F.W. Baskerville   +3 more
openalex   +2 more sources

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

open access: yesInterdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling   +13 more
wiley   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro   +5 more
wiley   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou   +6 more
wiley   +1 more source

Longest survivor of pulmonary atresia with ventricular septal defect without surgical intervention

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 1499-1507, April 2025.
Sang Zhou   +5 more
wiley   +1 more source

Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Ventricular enlargement and abnormal cerebrospinal fluid (CSF) circulation are closely associated in communicating hydrocephalus (NPH), yet their causal relationship remains unclear. Studying healthy populations may help clarify these mechanisms.
Pan Liu   +6 more
wiley   +1 more source

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