Results 171 to 180 of about 62,975 (258)

RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis. [PDF]

open access: yesMol Biomed
Yao X   +16 more
europepmc   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

open access: yesEpilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen   +15 more
wiley   +1 more source

Non-Hermitian dynamics in quantum anomalous Hall insulators. [PDF]

open access: yesSci Adv
Yi L   +6 more
europepmc   +1 more source

A prospective natural history study protocol for clinical trial readiness in synaptic disorders

open access: yesEpilepsia, EarlyView.
Abstract Objective STXBP1‐related disorder (STXBP1‐RD) and SYNGAP1‐related disorder (SYNGAP1‐RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems.
Jillian L. McKee   +38 more
wiley   +1 more source

The Seepage Characteristics of Single Rough Joint of Granite Based on NMR Technology: A Modified Cubic Law

open access: yesEnergy Science &Engineering, EarlyView.
The low‐field nuclear magnetic resonance (NMR) measurements are applied to investigate the seepage characteristics of the single rough joint. The purpose of this paper is to investigate the seepage characteristics of granite specimens with single‐joint channel under the different roughness, confining pressures and seepage pressures.
Hao Cheng, Xiujie Zhong
wiley   +1 more source

Impact of molecular tumor board on clinical outcomes in patients with refractory solid tumors: a real-world study. [PDF]

open access: yesOncologist
Ling Y   +14 more
europepmc   +1 more source

Flow Characteristics and Response Surface Methodology‐Based Pressure‐Loss Prediction Models for the Reverse Circulation Converter in Double‐Wall Drill Pipes

open access: yesEnergy Science &Engineering, EarlyView.
Flow characteristics and pressure loss mechanisms of a reverse circulation converter in dual‐wall drill pipes are systematically investigated using CFD and response surface methodology. The results reveal the dominant role of inertial dissipation and provide a predictive framework for optimizing converter design and operational parameters. ABSTRACT The
Mingming Geng   +8 more
wiley   +1 more source

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