Results 61 to 70 of about 62,975 (258)

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Atomic Tuning of Metal‐Support Interactions for Pathway‐Selective CO2 Photoreduction on TiO2

Advanced Science, EarlyView.
Single‐atom Fe and Cu catalysts anchored on TiO2 steer photocatalytic CO2 reduction toward distinct pathways. Fe sites favor rapid *CO desorption and selective CO formation, whereas Cu sites stabilize *CHO intermediates, enabling deep reduction and C─C coupling. Combined spectroscopy and DFT calculations reveal how metal–support interactions and oxygen
Dongyun Kim, Wonjae Ko, Byoung‐Hoon Lee, Sanghoon Kim, Yun Do Kim, Hyunsoo Ahn, Yoon Jung, Chan Woo Lee, Kug‐Seung Lee, Eunhee Gong, Junho Lee, Minho Kim, Taeghwan Hyeon, Su‐Il In   +13 more
wiley   +1 more source

Fault diagnosis for pump equipment based on transfer learning: the domain generalization method

Scientific Reports
In recent years, with the advent of machine learning technology, data-driven fault diagnosis has emerged as a prominent research area. However, since the necessity of training and test data has to follow an identical distribution, the conventional data ...
Weihong Wang, Xinwen Zhao, Yongfa Zhang, Tian Tan, Lizhi Jiang, Chen Wang, Liming Zhang   +6 more
doaj   +1 more source

Metallurgical Investigation of HSLA Steel Subjected to Underwater Explosion

Shock and Vibration, 1994
The metallurgical behaviour of HSLA steel subjected to underwater explosion is of prime importance because of its structural applications in underwater vehicles.
V. Bhujanga Rao, R. Rajendran, A.V. Jaykumar, K.H.B.S. Satyanarayana   +3 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Serum amino acid alterations in hyperuricemia: potential targets for renal disease prevention

Amino Acids
Observational studies have linked uric acid (UA) levels and kidney disease to amino acid homeostasis, but the causal relationship is unclear. This study aims to determine if elevated UA affects amino acid levels and whether amino acids mediate this ...
Qinglin Sheng, Yuqing Ma, Bingjie Geng, Jiahui Chen, Junfei Cheng, Su Liu, Rui Li, Xiangtong Li, Jing Wang, Hongtao Lu, Fangyuan Gao, Fu Gao   +11 more
doaj   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke

International Journal of Nanomedicine
Yuan Gao,1,2,* Ting-Lin Zhang,3,* Hong-Jian Zhang,1,2,* Jie Gao,3 Peng-Fei Yang1,2,4 1Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai, People’s Republic of China; 2School of Health
Gao Y, Zhang TL, Zhang HJ, Gao J, Yang PF   +4 more
doaj  

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

Comparative Effectiveness of Pharmacological, Non-Pharmacological, and Combined Strategies for Pain Relief During Colonoscopy: A Bayesian Network Meta-Analysis of Randomized Trials

Journal of Pain Research
Xiaonan Huang,1,* Shan Tian,2,* Lifan Xu,1,* Juhan Chen,1,* Hao Wang,3 Tingting Mai,1 Lei Shi,1 Han Wang,4 Mengcheng Cai,5 Fanfu Fang1 1Department of Rehabilitation Medicine, Changhai Hospital, Naval Medical University ...
Huang X, Tian S, Xu L, Chen J, Wang H, Mai T, Shi L, Wang H, Cai M, Fang F   +9 more
doaj