Results 181 to 190 of about 335,223 (267)

Real‐World Effectiveness and Safety of Upadacitinib in Crohn's Disease: Insights From the Eneida Registry

United European Gastroenterology Journal, Volume 14, Issue 4, May 2026.
ABSTRACT Background Upadacitinib (UPA) is the first oral Janus kinase (JAK) inhibitor approved for the treatment of Crohn's disease (CD). Real‐world data, particularly from large nationwide cohorts, remain limited. This study aimed to evaluate the real‐world effectiveness, safety, and treatment persistence of UPA in patients with CD.
M. Iborra, B. Botella, M. D. Martín‐Arranz, D. Ceballos, C. Martínez‐Pascual, A. Garrido, P. Varela, M. Moreta, E. Brunet‐Mas, Y. González‐Lama, E. Rodríguez‐González, M. Vicuña, J. P. Gisbert, I. Ordás, F. Argüelles‐Arias, J. Tosca‐Cuquerella, R. Vicente‐Lidón, M. Sierra‐Ausín, I. Rodríguez‐Lago, D. Martín‐Rodríguez, J. M. Paredes, B. Sicilia, I. García de la Filia, N. Jiménez, M. Barreiro‐de Acosta, E. Betoré, I. Ferrer‐Bradley, L. García‐Alles, J. M. Huguet, S. Castellet‐Farrús, M. J. García, A. Gutiérrez‐Casbas, Á. Ponferrada‐Díaz, L. Ramos, M. Calafat, I. Vera, C. Suárez‐Ferrer, E. Fernández‐Velado, S. Rodríguez‐Sánchez, A. Mínguez, A. Mancebo, J. Barrio, S. Lario, D. R. de La Cruz, Alejandro Hernández‐Camba, C. Rodríguez‐Gutiérrez, M. Chaparro, E. Ricart, L. Almenara‐Michelena, A. Balaguer, E. Domènech, P. Nos   +51 more
wiley   +1 more source

Development and Psychometric Validation of the Spanish Version of the Experience of Living With Chronic Heart Failure-University of Navarra Scale. [PDF]

Nurs Health Sci
Olano-Lizarraga M, Saracíbar-Razquin M, Zaragoza-Salcedo A, Cobo-Sanchez JL, Pérez-García S, Simón-Ricart A, Ara-Lucea P, Jimeno-San Martín L, Ducay-Eguillor M, De La Torre-Lomas N, Pérez-Herreros J, Moro-Tejedor N, Guerra-Sánchez L, Cambra-Vidart L, Salinas-Urra S, Rodriguez-Blazquez C, Forjaz MJ, Ayala A, Martín-Martín J.   +18 more
europepmc   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Dual and context-dependent role of the interleukin-33/soluble suppression of tumorigenicity 2 axis in obesity and adipose tissue inflammation. [PDF]

Mol Med
Casado M, Gómez-Ambrosi J, Ramírez B, Becerril S, Rodríguez A, Valentí V, Moncada R, Silva C, Escalada J, Frühbeck G, Catalán V.   +10 more
europepmc   +1 more source

Nationwide Implementation of Double Reflex Testing for Hepatitis Delta in Spain: Results From the Retrospective Phase of the Spain‐DDR Study

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 10, Page 1390-1397, May 2026.
Nationwide implementation of double reflex testing for hepatitis delta in Spain markedly increased anti‐HDV and HDV viral load testing between 2022 and 2024, enabling national seroprevalence estimates. Despite this progress, substantial regional heterogeneity persists, highlighting the need for standardised reflex diagnostic protocols.
Ana Alberola, Adolfo de Salazar, Ana Fuentes, Raquel Carracedo, Marta Illescas‐López, María del Carmen Rodríguez Baños, Carolina Freyre, Berta Becerril, Isabel Viciana, Inmaculada López‐Rodríguez, Natalia Montiel, Ana María Domínguez Castaño, María Pilar Luzón‐García, Encarnación Ramírez Arellano, Carmen Liébana‐Martos, Francisco Franco Álvarez de Luna, María del Carmen Lozano, Begoña Palop, Antonio Sampedro, Ana Belén Pérez, Sonia Algarate, Susana Rojo Alba, Pablo Fraile, Dolores Ocete, María Jesús Alcaraz, Juan Carlos Rodríguez, Francisco Javier Hernández‐Felices, Olalla Martínez, Victoria Domínguez, Nieves Orta, Dolores Gómez, Carmen Cortell, Jorge Camacho, Susana Sabater, Luis Ángel Iglesias Sánchez, Yasmina Martín, Aldara Vallejo, Lourdes Molina, María Aroca, Beatriz Castro, Magdalena Lara, María José Pena, Ana Rodríguez‐Fernández, Alejandro González Praetorius, José Joaquín Blas, Alicia Beteta, César Gómez, María José Rodríguez, Soledad Illescas, Melanie Abreu, Julio García Díez, Inocencio Beltrán, Marta Sandoval Torrientes, Ruth Sáez, Teresa Martín, Pilar Tajada Alegre, Belén Lorenzo, María Teresa García Valero, Isabel Jiménez Sansegundo, Susana García‐de Cruz, Sonsoles Garcinuño, Miguel Ángel Sáiz, Santiago Muñoz, Isabel Fernández, Helena Miriam Lorenzo Juanes, María Reyes Vidal‐Acuña, Luz María Moldes, Noelia Calvo, Matilde Trigo, María José Gude, Patricia Ordóñez, Sandra Cortizo, Miriam Blasco, Mayra Sigcha, Iker Falces, Juan Carlos Galán, Ana Arribi, Roberto Alonso, Asunción Iborra, María Jesús del Amor Espín, Eva Cascales, Cayetano Pérez, Pablo Fernández, María Dolores Navarro, María Luz Nuñez, Jorge Galán Ros, Luis Javier Gil‐Gallardo, Ana Miqueleiz, Gabriel Reina, Luis Elorduy, Mikele Macho, Carmen Gómez, Paloma Liendo, Yolanda Salicio, Antonio Aguilera, Federico García   +95 more
wiley   +1 more source

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Epidemiology of Progressive Supranuclear Palsy in Navarre, Spain: A Population-Based Study. [PDF]

Eur J Neurol
Arrondo Gómez P, Vicente E, Martí-Andrés G, Sánchez Ruiz de Gordoa J, Gastón I, Clavero P, Valentí R, Delfrade J, Erro ME.   +8 more
europepmc   +1 more source

Association Between Mediterranean Diet and the Incidence of Adult-Onset Asthma in the SUN Project: A Spanish Prospective Cohort Study. [PDF]

Respirology
Errasti Viader J, de la Fuente-Arrillaga C, Campo Ezquibela A, Sayon-Orea C, Martínez-González MÁ, Bes-Rastrollo M.   +5 more
europepmc   +1 more source

The ILEOSTIM trial: A multicentre randomised controlled trial evaluating the impact of efferent loop stimulation prior to ileostomy reversal on postoperative ileus

Colorectal Disease, Volume 28, Issue 5, May 2026.
Abstract Background Strategies to optimise bowel function before stoma reversal surgery (SRS) are needed to improve postoperative outcomes. Efferent bowel stimulation (EBS) prior to stoma closure has been proposed as a potential strategy to reduce postoperative ileus (POI) incidence and improve the patient's postoperative course.
Jorge Arredondo, Adriana Uriz, Irene Oliva, José I. Martín, Christian N. Iglesias, Ekta Choolani, Ainhoa Valle, Javier Rivera, Sebastián Jerí‐McFarlane, Juan M. Romero, Carolina González, Alicia Alvarellos, Marta Tasende, Lourdes Gómez, Laura Lázaro, Blanca Montcusí, Patricia Tejedor, Jeancarlos Trujillo‐Díaz, Alicia Ruiz de la Hermosa, Jorge Baixauli, Jorge M. Núñez‐Córdoba, Daniel Aliseda, ILEOSTIM Trial Group, Enrique Pastor, Jesús Fernández, Amaya Villafañe, María Beltrán, Ana Urioste, Herminia Lara, María Victoria Diago, Tania Gotor, Isabel Cifrian, Luis Miguel Jiménez, Elena Hurtado, Carlos Pastor, Fernando Labarga, Rosalía Velasco, Vicente Simó, Teresa Calderón, Mahur Esmailli, Patricia Ortega, María Luisa de Fuenmayor, Vanesa Serrano, Isabel Prieto, Lequerica Cabello, Carlos Sánchez, Alberto Bravo, Lucrecia Rodríguez, Juana Escudero, Alejandro Morales, Maria Cruz Correa, Naybet Pérez, Juan Carlos Martín, Pilar Concejo, Juan Ramón Gómez, Clara Martínez, Javier Atienza, Alejandro Gil, Margarita Gamundi, Aina Ochogavía, Enrique Colás, Naila Pagés, Susana González, Laia Cabré, Marta Pascual, Mayra Rebeka Abad, Isabel Seco, Víctor Valbuena, Rubén Caina, Estefanía Sánchez, Alicia Ferrer, Virginia Jiménez, Salvadora Delgado, Mireia Lázaro, Rubén Rodríguez, Adoración Meana, Paola Lora   +76 more
wiley   +1 more source

Improving the learning curve in monoportal endoscopic lumbar surgery: Development and validation of a porcine training model. [PDF]

PLoS One
Olías-Ortiz L, Llombart-Blanco R, Abizanda-Sarasa G, Lacave-Mas I, Valverde-Gestoso C, Alfonso-Olmos M.   +5 more
europepmc   +1 more source