Results 111 to 120 of about 188,023 (237)
Advanced Science, EarlyView.Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee +5 more
wiley +1 more source
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source
Forecastle and quarterdeck : protest, discipline and mutiny in the Royal Navy, 1793-1814 [PDF]
This thesis is a study of disputes and conflicts between officers and men in the Royal Navy between 1793 and 1814. The first part is a general introduction to shipboard life and work, discipline, resistance and protest, and to the sailors' culture ...
Neale, Jonathan Sayles
core
The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
Advanced Science, EarlyView.Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi +11 more
wiley +1 more source
Vice Admiral Jan E. Tighe, first female commander of a numbered fleet in U.S. Navy history, talks about information warfare [PDF]
, 2014 An article from CHIPS, the Department of the Navy information technology magazineSponsored by the DON Chief Information Officer and the DON Enterprise Software Initiative (ESI) Software Product ...
CHIPS Magazine
core
Advanced Science, EarlyView.PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan +18 more
wiley +1 more source
Advanced Science, EarlyView.Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source
Experiments on Nonlocal Fluid‐Flow Metamaterials
Advanced Science, EarlyView.A nonlocal fluid‐flow metamaterial composed of standard microfluidic tubes and connectors is designed. Hence, the current of the system at one position depends on the gradient of fluid flow at many other positions, leading to unusual alternating backward and forward laminar flows of water.
Ke Wang, Yi Chen, Martin Wegener
wiley +1 more source
, 2008 This report summarizes the results of an analysis of whether individual augmentation (IA) deployment affects retention rates for Navy enlisted personnel and junior officers.
Fricker, Ronald D. Jr. +1 more
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Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids
Advanced Science, EarlyView.This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia +8 more
wiley +1 more source