Results 41 to 50 of about 313,193 (294)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Covid-19 Prediction Model Using Data Mining Algorithms

Al-Mustansiriyah Journal of Science, 2022
From 2019 until today, the whole world is panicking due to the pandemic of the Corona virus or the so-called COVID-19, so it was inevitable to search for a way to predict the disease before it occurs.
Zahraa Naser Shah weli
doaj  

Reforming Primary Health Care in Akwa Ibom State

Ibom Medical Journal, 2006
INTRODUCTION: Society and all social systems are dynamic which means that changes occur continuously.  Some changes occur spontaneously while others are planned and executed.
Udoh NB
doaj   +1 more source

Radiological markers of neurological manifestations of post-acute sequelae of SARS-CoV-2 infection: a mini-review

Frontiers in Neurology, 2023
The neurological impact of COVID-19 is a rising concern among medical professionals, as patients continue to experience symptoms long after their recovery.
Olivia Cull, Olivia Cull, Lina Al Qadi, Lina Al Qadi, Josiane Stadler, Josiane Stadler, Mykella Martin, Mykella Martin, Antonios El Helou, Antonios El Helou, Antonios El Helou, Antonios El Helou, Jeffrey Wagner, Jeffrey Wagner, Danica Maillet, Ludivine Chamard-Witkowski, Ludivine Chamard-Witkowski, Ludivine Chamard-Witkowski   +17 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Geochemical characteristics and genesis of element enrichment of niobium-rich-rare earth metal layer in Longtan Formation of Zhina coalfield

Meitian dizhi yu kantan
BackgroundWith the increasing demand for strategic metals and the gradual depletion of traditional metal deposit resources, coal and coal-bearing rock series are considered to be potential sources of rare metals, and coal series associated has become one
Yunlong DING, Fangfa WANG, Bi LI, Lifang TANG, Yi YANG, Shangyuan LI, Xiaofang WANG, Yinhong ZOU, Yang WANG   +8 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

DH-LAB-NB/DHLAB v0.1-alpha

, 2019
No description ...
DH-LAB-NB, Yngvil Beyer
core   +1 more source