Results 91 to 100 of about 150,411 (276)

Feasibility and Preliminary Efficacy of a Guided Self‐Help Digital Intervention for Adults With Food Insecurity, Recurrent Binge Eating, and Type 2 Diabetes Mellitus: A Pilot Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Food insecurity is increasingly linked to binge eating and weight‐related health issues like type 2 diabetes mellitus, but no eating disorder interventions have been tested among individuals with food insecurity. We conducted a single‐arm pilot test of FoodSteps‐FI, a guided self‐help digital intervention for binge eating adapted for
Andrea K. Graham, Rebecca L. Flynn, Isabel R. Rooper, Chidiebere Azubuike, Lindsay D. Lipman, Adrian Ortega, Leah M. Parsons, Graham C. Miller, Damien Lekkas, Jennifer E. Wildes   +9 more
wiley   +1 more source

PMP22 exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E [PDF]

, 2017
OBJECTIVE: To determine whether predicted fork stalling and template switching (FoSTeS) during mitosis deletes exon 4 in peripheral myelin protein 22 KD (PMP22) and causes gain‐of‐function mutation associated with peripheral neuropathy in a family with ...
Bai, Yunhong, Connolly, Anne M, Grider, Tiffany, Kamholz, John, Lupski, James R, Shy, Michael E, Wang, David S, Wu, Xingyao, Zaidman, Craig   +8 more
core   +2 more sources

Adolescent and Young Adult Perceptions of Online Versus In‐Person Cognitive‐Behavioral Therapy for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This preliminary study investigated adolescent and young adult (AYA) perceptions of online cognitive‐behavioral therapy (CBT) for eating disorders (EDs), examining attitudes toward online versus face‐to‐face treatment and perceived effectiveness of online CBT interventions.
Jasmine Thomas, Ava M. Pasewicz, Marley G. Billman Miller, Robert Friedberg, Jamal H. Essayli   +4 more
wiley   +1 more source

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public–private partnerships

Computational and Structural Biotechnology Journal, 2016
Microphysiological systems (organs-on-chips, tissue chips) are devices designed to recapitulate human physiology that could be used to better understand drug responses not easily addressed using other in vivo systems or in vitro animal models.
Christine A. Livingston, Kristin M. Fabre, Danilo A. Tagle   +2 more
doaj   +1 more source

Clinical pharmacology as a foundation for translational science. [PDF]

, 2011
The evolution of enabling technologies and their associated perspectives into molecular mechanisms underlying disease has extended beyond the abilities of scientific and clinical structures to advance their translation into new algorithms that improve ...
Hohl, R J., Kearns, G L., Swan, S J., Terzic, A, Waldman, Scott A.   +4 more
core   +2 more sources

Delayed and deferred surgery associated with cenobamate use in people with drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Cenobamate has been shown to be an effective antiseizure medication for some patients with drug‐resistant focal epilepsy being considered for epilepsy surgery. This retrospective single‐center study evaluated whether surgery was obtained within 12 months for patients who received cenobamate as a treatment during the presurgical ...
Jacob Pellinen, Stefan Sillau, Aimee Bui, Alexandra Danciutiu, Lesley Kaye, Ashvin Sood, Louis Ferrari, William E. Rosenfeld, Christopher Elder   +8 more
wiley   +1 more source

Developing Robust Human Liver Microsomal Stability Prediction Models: Leveraging Inter-Species Correlation with Rat Data

Pharmaceutics
Objectives: Pharmacokinetic issues were the leading cause of drug attrition, accounting for approximately 40% of all cases before the turn of the century.
Pranav Shah, Vishal B. Siramshetty, Ewy Mathé, Xin Xu   +3 more
doaj   +1 more source

Predictions for the fracture toughness of cancellous bone of fracture neck of femur patients [PDF]

, 2016
Current protocol in determining if a patient is osteoporotic and their fracture risk is based on dual energy X-ray absorptiometry (DXA). DXA gives an indication of their bone mineral density (BMD) which is the product of both the porosity and density of ...
Adams, G. K., Cook, R. B., Zioupos, Peter   +2 more
core  

Long-term Symptomatic, Functional, and Work Outcomes of Carpal Tunnel Syndrome among Construction Workers [PDF]

, 2016
BACKGROUND: The long-term outcomes of carpal tunnel syndrome (CTS) including symptoms, functional status, work disability, and economic impact are unknown. METHODS: We conducted a retrospective study of 234 active construction workers with medical claims
Amick, Armstrong, Cagle, Dale, Daniell, Daniell, DeStefano, Dong, Foley, Forde, Franklin, Franzblau, Gardner, Gardner, Gimeno, Glazner, Gorsche, Hudak, Ilmarinen, Katz, Keith, Kuorinka, Levine, Lipscomb, Louie, Manktelow, Padua, Pensy, Probst, Resende, Rosecrance, Salerno, Spector, Turner, Ware, Welch, Wellman   +36 more
core   +2 more sources

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source