Results 231 to 240 of about 81,769 (307)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Nanotoxicity of Ultrasmall Silver Nanoclusters to Cyanobacteria. [PDF]

Toxics
Wu X, Zhang L, Yin M, Han X, Zhou G, Luan G, Sun X, Wang W, Han Z, Lu X.   +9 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

NCS Report 13: Quality control in brachytherapy: Current practice and minimum requirements

, 2000
A.H.L. Aalbers, W.J.F. Dries, J.L.M. Venselaar, B. Schaeken, I.K.K. Kolkman-Deurloo, R.J.M. Elfrink, H.J. Van Kleffens, A. Rijnders   +7 more
core   +1 more source

Biogenic synthesis of Ag-ZnO nanocomposites <i>via</i> sumac (<i>Rhus coriaria</i> L.) extract for synergistic photocatalytic degradation of Congo red and broad-spectrum antimicrobial activity. [PDF]

RSC Adv
Qasim AK, Mustafa LL, Faris AJ, Hamad SM.   +3 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

NCS Report 14: Quality control of sealed beta sources in brachytherapy

, 2004
W.J.F. Dries, A.H.L. Aalbers, M. Piessens, J. Van der Marel, H. De Vroome, D.R. Schaart, H.J. Van Kleffens, R.P. Kollaard, J.P.A. Marijnissen   +8 more
core   +1 more source

Structural and optical properties of ligand-free noble metal nanoclusters synthesized by ns-pulsed laser ablation at the argon-water interface. [PDF]

Nanoscale Adv
Concas GC, Gisbert M, Tahir, Gonzaga N, Enrichi F, Safonova A, Cassetta M, Reichenberger S, Fromme T, Cuin A, Aucelio R, Saint'Pierre TD, Dos Santos Carvalho IC, Afonso de Andrade W, Khan R, Ahmed Z, Farooq S, Mello A, Daldosso N, Del Rosso T.   +19 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Electrophysiological readout of ACTH-related neuroendocrine-immunomodulatory treatment response in infantile epileptic spasms syndrome: suppression of scalp ripple propagation networks. [PDF]

Front Immunol
Feng G, Dai W, Yang Y, Liu X, Li H, Peng B, Che Y, Li X, Wang J, Zhou Q, Yan J, Fang F, Zhong JM, Deng J, Zhou L, Yang X.   +15 more
europepmc   +1 more source