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The lingering effects of Neanderthal introgression on human complex traits

open access: goldeLife, 2023
The genetic variants introduced into the ancestors of modern humans from interbreeding with Neanderthals have been suggested to contribute an unexpected extent to complex human traits.
Xinzhu Wei   +9 more
doaj   +3 more sources

Late Pleistocene Neanderthal exploitation of stable and mosaic ecosystems in northern Iberia shown by multi-isotope evidence [PDF]

open access: hybridQuaternary Research, 2023
During the last glacial period, rapidly changing environments posed substantial challenges to Neanderthal populations in Europe. Southern continental regions, such as Iberia, have been proposed as important climatic “buffer” zones during glacial phases ...
Sarah Pederzani   +5 more
openalex   +2 more sources

Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

open access: yesCommunications Biology, 2023
The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate ...
Pierre Faux   +32 more
doaj   +2 more sources

The Neanderthal niche space of Western Eurasia 145 ka to 30 ka ago

open access: yesScientific Reports
Neanderthals occupied Western Eurasia between 350 ka and 40 ka ago, during the climatically volatile Pleistocene. A key issue is to what extent Neanderthal populations expanded into areas of Western Eurasia and what conditions facilitated such range ...
Peter M. Yaworsky   +2 more
doaj   +2 more sources

Neanderthal teeth from Lezetxiki (Arrasate, Iberian Peninsula): New insights and reassessment [PDF]

open access: hybridAmerican Journal of Biological Anthropology, 2023
Objectives: We reassess the taxonomic assignment and stratigraphic context of a permanent upper first molar and a permanent lower third premolar recovered from the archeological site of Lezetxiki in the North of the Iberian Peninsula.
Diego López‐Onaindia   +4 more
openalex   +2 more sources

Neanderthal coexistence with Homo sapiens in Europe was affected by herbivore carrying capacity [PDF]

open access: goldScience Advances, 2023
It has been proposed that climate change and the arrival of modern humans in Europe affected the disappearance of Neanderthals due to their impact on trophic resources; however, it has remained challenging to quantify the effect of these factors.
Marco Vidal‐Cordasco   +3 more
openalex   +2 more sources

Neanderthal Hunting Weapons Re-Assessed: A Tip Cross-Sectional Area Analysis of Middle Palaeolithic Point Assemblages from South Eastern France

open access: yesQuaternary, 2023
There are many opinions and arguments about the types of weapons that Neanderthals may have used. We list five assumptions about Neanderthal weapon-assisted hunting and suggest that the tip cross-sectional area (TCSA) approach may be used to assess these,
Marlize Lombard, Marie-Hélène Moncel
doaj   +2 more sources

Calculated or caring? : Neanderthal healthcare in social context [PDF]

open access: bronze, 2018
Explanations for patterns of healed trauma in Neanderthals have been a matter of debate for several decades. Despite widespread evidence for recovery from injuries or survival despite impairments, apparent evidence for healthcare is given limited ...
Hitchens, Gail Elizabeth   +3 more
core   +3 more sources

Quantifying the contribution of Neanderthal introgression to the heritability of complex traits

open access: yesNature Communications, 2021
We lack a comprehensive understanding of how Neanderthal ancestry influences human traits. This study finds that regions with Neanderthal ancestry are broadly depleted of trait-associated variation; yet, introgressed variants likely contributed to human ...
Evonne McArthur   +2 more
doaj   +2 more sources

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations

open access: yesBMC Biology, 2022
Background Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum.
Dora Koller   +7 more
doaj   +2 more sources

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