Results 91 to 100 of about 508,942 (290)

Taxonomy of Subkilometer Near-Earth Objects from Multiwavelength Photometry with RATIR

The Astronomical Journal
We present results from observations of 238 near-Earth objects (NEOs) obtained with the RATIR instrument on the 1.5 m robotic telescope at San Pedro Martir’s National Observatory in Mexico, in the frame of our multiobservatory, multifilter campaign.
S. Navarro-Meza, D. E. Trilling, M. Mommert, N. Butler, M. Reyes-Ruiz   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Discovery and Characterization of Earth-crossing Asteroid 2024 YR4

The Astrophysical Journal Letters
We describe observations and physical characteristics of Earth-crossing asteroid 2024 YR _4 , discovered on 2024 December 27 by the Asteroid Terrestrial-impact Last Alert System.
Bryce T. Bolin, Josef Hanuš, Larry Denneau, Roberto Bonamico, Laura-May Abron, Marco Delbo, Josef Ďurech, Robert Jedicke, Leo Y. Alcorn, Aleksandar Cikota, Swayamtrupta Panda, Henrique Reggiani   +11 more
doaj   +1 more source

The Astronomical Hub: A Unified Ecosystem for Modern Astronomical Research

Galaxies
We present the conceptual framework of the Astronomical Hub (AstroHub), a unified platform combining various optical instruments at a single observatory.
Yerlan Aimuratov, Vitaliy Kim, Aleksander Serebryanskiy, Denis Yurin, Maxim Krugov, Chingiz Akniyazov, Saule Shomshekova, Maxim Makukov, Gaukhar Aimanova, Rashit Valiullin, Raushan Kokumbaeva, Alan Kazkenov, Chingis Omarov   +12 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Near-Earth object 2012XJ112 as a source of bright bolides of achondritic nature [PDF]

, 2014
J. M. Madiedo, J. M. Trigo‐Rodríguez, I. P. Williams, Н. А. Коновалова, J. L. Ortiz, A. J. Castro‐Tirado, S. Pastor, J.A. de los Reyes, J. Cabrera-Caño   +8 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Near-Earth-Object identification over apparitions usingn-body ranging [PDF]

, 2006
Mikael Granvik, K. Muinonen
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The analysis of the state of development of devices for cleaning orbits in near-Earth space from large-sized space debris objects

, 2022
V. I. Trushlyakov, Vadim Yudintsev, V. A. Urbansky, S. Yu. Onishchuk   +3 more
openalex   +1 more source