Results 101 to 110 of about 15,725 (313)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Optimal detection of near-earth objects [PDF]

, 1997
Improved technology and search strategies could significantly increase debris detection rates and tracking accuracies with modest investment. Improving the focal planes of current telescopes could significantly increase detection rates. For large systems, proportional increases in aperture area and array size are appropriate.
openaire   +2 more sources

Searching for the first near-Earth object family [PDF]

, 2012
E. Schunová, Mikael Granvik, Robert Jedicke, Giovanni F. Gronchi, R. J. Wainscoat, Shinsuke Abe   +5 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Asteroids discovered in the Baldone Observatory between 2017 and 2022: The orbits of asteroid 428694 Saule and 330836 Orius

Open Astronomy
We discovered 83 asteroids at the Baldone Astrophysical Observatory (MPC code 069) in 2017–2022. We studied one of the dynamically interesting Apollo (Near Earth object) observed at the Baldone Astronomical Observatory, namely 428694 Saule (2008 OS9) and
Wlodarczyk Ireneusz, Černis Kazimieras, Eglitis Ilgmar   +2 more
doaj   +1 more source

Comet/asteroid protection system (CAPS): A space-based system concept for revolutionizing earth protection and utilization of near-earth objects [PDF]

, 2003
Daniel D. Mazanek, Carlos M. Roithmayr, Jeffrey Antol, Linda Kay-Bunnell, M. Werner, Sang Young Park, Renjith R. Kumar   +6 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Global vulnerability to near-Earth object impact [PDF]

, 2010
Nicholas J. Bailey, G.G. Swinerd, Hugh G. Lewis, R.L. Crowther   +3 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Near Earth Objects

, 2006
The word planet comes from Greek planetes, wanderers, because the planets appear to wander across the celestial sphere, contrary to the fixed stars. This thesis presents several methods for using this motion to distinguish between stars and solar system objects in order to detect and track NEOs, Near Earth Objects: Asteroids and comets following paths ...
openaire   +1 more source