Results 41 to 50 of about 508,942 (290)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

DOME ENCLOSURE: CLAM SHELL DESIGN [PDF]

Journal of Astronomy and Space Sciences, 2002
Near Earth Object Patrol Team (National Research Lab.) at KAO and YSTAR team at Yonsei University Observatory jointly developed a dome enclosure to be installed abroad together with a survey telescope.
Hong-Suh Yim, Yong-Woo Kang, Yong-Ik Byun, Hong-Kyu Moon, Won-Yong Han   +4 more
doaj   +1 more source

The Neoshield project for Near-Earth object impact threat mitigation [PDF]

, 2016
Every day Earth is hit by around 100 tonnes of cosmic material, most of it comes in the form of dust or small rocks, which burn up as meteors in the atmosphere.
Drube, Line, Harris, Alan W.
core   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Impact hazard protection efficiency by a small kinetic impactor [PDF]

, 2013
In this paper the ability of a small kinetic impactor spacecraft to mitigate an Earth-threatening asteroid is assessed by means of a novel measure of efficiency.
C. Colombo, Harris A. W., J. P. Sanchez, Olds J., Opik E. J., Schaffer M. G., Shapiro I. I.   +6 more
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Asteroid Impact Hazard Warning from the Near-Earth Object Surveyor Mission

The Planetary Science Journal
NASA’s Near-Earth Object Surveyor mission, scheduled for launch in 2027 September, is designed to detect and characterize at least two-thirds of the potentially hazardous asteroids with diameters larger than 140 m in a nominal 5 yr mission. We describe a
Oliver Lay, Joe Masiero, Tommy Grav, Amy Mainzer, Frank Masci, Edward Wright   +5 more
doaj   +1 more source

The Population of Tiny Near-Earth Objects Observed by NEOWISE [PDF]

, 2013
Only a very small fraction of the asteroid population at size scales comparable to the object that exploded over Chelyabinsk, Russia has been discovered to date, and physical properties are poorly characterized.
Bauer, J., Clyne, E., Cukrov, G., Cutri, R. M., Grav, T., Mainzer, A., Masci, F., Masiero, J., Nugent, C. R., Stevenson, R., Wright, E. L.   +10 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source